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TitleUsability of blood examinations and imaging examinations in the diagnosis of ocular sarcoidosis
PurposeBlood examinations including angiotensin-converting enzyme (ACE), and imaging examinations have been used for diagnosis of sarcoidosis. Recently, soluble interleukin-2 receptor (sIL-2R) was included in Diagnostic Standard and Guideline for Sarcoidosis 2015 (Japan Society of Sarcoidosis and other Granulomatous Disorders). The aim of this study was to evaluate the clinical usefulness of blood examinations including sIL-2R and imaging examinations in the diagnosis of ocular sarcoidosis.
MethodsThis retrospective study included 94 cases (male: 27 cases, female: 67 cases) with ocular sarcoidosis who visited Hokkaido University Hospital from 2011 to 2015. 124 cases (male: 56 cases, female: 68 cases) of other uveitis patients were also included as controls. Blood examinations including ACE, KL-6, sIL-2R, serum calcium (s-Ca) and imaging examinations including bilateral hilar lymphadenopathy (BHL) detected by chest X-ray and/or chest computed CT scan were examined.
ResultsThe sensitivity and the specificity of ACE were 44.0% and 97.9% respectively, and those of KL-6 were 29.5% and 89.2%, those of sIL-2R were 76.5% and 89.6%, those of s-Ca were 12.4% and 95.0%. As for the imaging examinations, the sensitivity and the specificity of BHL with chest X-ray were 29.0% and 97.6% and those of chest computed CT scan were 84.1% and 100%.
ConclusionIt was suggested that sIL-2R and chest computed CT scan were useful in the diagnosis of ocular sarcoidosis.
Conflict of interestNo
Author 1
Last nameSUZUKI
Initials of first name(s)K
DepartmentFaculty of Medicine and Graduate School of Medicine, Hokkaido University
CitySapporo
CountryJapan
Author 2
Last nameNamba
Initials of first name(s)K
CitySapporo
CountryJapan
Author 3
Last nameMizuuchi
Initials of first name(s)K
CitySapporo
CountryJapan
Author 4
Last nameIwata
Initials of first name(s)D
CitySapporo
CountryJapan
Author 5
Last nameIto
Initials of first name(s)T
CitySapporo
CountryJapan
Author 6
Last nameOhno
Initials of first name(s)S
CitySapporo
CountryJapan
Author 7
Last nameKitaichi
Initials of first name(s)N
CitySapporo
CountryJapan
Author 8
Last nameIshida
Initials of first name(s)S
CitySapporo
CountryJapan