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Presentation preference Poster and Rapid fire
TitleThe paradigm shift of the treatment for Paediatric uveitis - the use of disease modifying biologics
PurposePaediatric uveitis may have a debilitating impact upon children due to treatment failure and disease progression resulting in Paediatric Cataract and Glaucoma. Biologic agents are a relatively new treatment with promising outcomes. Traditionally corticosteroids (both topical and oral) and immunosuppressive agents such as methotrexate were used for the treatment of uveitis.
MethodsRetrospective, chart review demographic data, treatment efficacy, failure and safety over an 8-year period of 27 paediatric uveitis patients (49 eyes) at a quaternary referral eye hospital in Sydney, Australia treated with biologic agents followed up to 1 year were included.
ResultsOf the 27 patients (49 eyes), 43% had increased IOP, 40% Cataract and 25% some form of glaucomatous optic neuropathy at presentation. Biologic therapy over 1 year was effective with prednisolone reduced to <5mg/day in 5 of 6 patients (83%), systemic steroid-sparing agents was reduced to ≤ 1 in 2 of 4 patients (50%), and cessation of topical steroid achieved in 12 of 41 of eyes (29%). Cessation of topical steroids was achieved in 7/45 eyes (16% (95% CI, 7.7-28.8)) at 6 weeks of follow-up, 10/43 eyes (23% (95% CI, 13.2-37.7)) at 6 months of follow-up, and 12/41 eyes (29% (95% CI, 17.6-44.5)) at 12 months of follow-up.
ConclusionBiologic therapy was demonstrated to be effective and safe in paediatric uveitis in the real-world setting. It resulted in reduction of corticosteroid burden, and number of steroid-sparing agents.
Conflict of interestNo
Author 1
Last nameZAGORA
Initials of first name(s)SL
DepartmentDiscipline of Ophthalmology, University of Sydney
CitySydney
CountryAustralia
Author 2
Last nameOh
Initials of first name(s)L
DepartmentDiscipline of Ophthalmology, University of Sydney
CitySydney
CountryAustralia
Author 3
Last nameMcCluskey
Initials of first name(s)PM
DepartmentDiscipline of Ophthalmology, University of Sydney
CitySydney
CountryAustralia