Objective evaluation of the intraocular inflammation using Swept-Source Optical coherence tomography
Purpose
To develop an objective intraocular inflammation composite score.
Methods
Healthy controls, patients with inactive uveitis and patients with active uveitis were included. The sample was stratified according to the standard degree of inflammation. SS-OCT images
were processed by different algorithms. We studied 8 items in 3 domains: anterior, intermediate and posterior, which were correlated with SUN, NEI and VAS-10 activity scales.
Results
We analyzed 20 healthy eyes and 234 eyes with uveitis. VAS-10 showed a moderate significant correlation with respect to the VA LogMAR (r = 0.415, p <0.0001). After ranking, the chosen items for the final score were: the number of cells in the anterior chamber (NCAC) for the anterior domain, the relative intensity of the vitreous (HD-RIVC) for the intermediate domain and, in the posterior domain: the over-red threshold (ORT) and the central macular thickness (CMT). All selected items showed a high discriminatory power between active and inactive eyes, as well as significant correlation with the corresponding clinical scales and VAS-10. Final composite score (SS-OCT-UAS) was calculated as follows: SS-OCT-UAS=(NCACx0.143)+(HD RIVCx0.294)+(ORTx0.609)+(CMTx0.945).
Conclusion
The global intraocular inflammation can be evaluated objectively, continuously, consistently and in a valid manner through the analysis and a combined weighting of different SS-OCT scans.
Conflict of interest
No
Author 1
Last name
SAINZ DE LA MAZA
Initials of first name(s)
M
Department
Hospital Clinic
City
Barcelona
Country
Spain
Author 2
Last name
SERRANO
Initials of first name(s)
A
Department
Hospital Clinic
City
Barcelona
Country
Spain
Author 3
Last name
ESQUINAS
Initials of first name(s)
C
Department
Hospital Clinic
City
Barcelona
Country
Spain
Author 4
Last name
MONTASELL
Initials of first name(s)
A
Department
Hospital Clinic
City
Barcelona
Country
Spain
Author 5
Last name
GASCON
Initials of first name(s)
J
Department
Hospital Clinic
City
Barcelona
Country
Spain
Author 6
Last name
MESQUIDA
Initials of first name(s)
M
Department
IDIBAPS
City
Barcelona
Country
Spain
Author 7
Last name
ADAN
Initials of first name(s)
A
Department
Hospital Clinic
City
Barcelona
Country
Spain
Author 8
Last name
LLORENS
Initials of first name(s)
V
Department
Hospital Clinic
City
Barcelona
Country
Spain
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