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TitleRisk factors associated with persistent ocular inflammation in patients with Vogt-Koyanagi-Harada disease
PurposeTo identify risk factors for persistent ocular inflammation in patients with Vogt-Koyanagi-Harada disease(VKH).
MethodsThe clinical data of 52 patients diagnosed with VKH and treated with high dose steroid therapy, with whom we could followed up over one year were used for the statistical analysis. We defined the persistent VKH, which had any of inflammation with either more than "2+" cells (10-30 cells per field) in the anterior chamber, iris posterior synechia, or posterior ocular inflammation, which reguired additional treatments. We statistically investigated the association with the persistent VKH and their clinical data including age, gender, clinical findings, laboratory findings (blood, cerebrospinal fluid), and period from onset to treatment by using multivariate analysis.
ResultsThere were 18 (35%) male and 34 (65%) female with a mean age of 49.9±17.1 years. 12 of 52 patients (23%) had chronic ocular inflammation. The mean follow-up period was 34.8±23.4months. The estimated glomerular filtration rate (eGFR) in blood examination significantly associated with chronic VKH (P=0.0328). Age, gender, the number of cerebrospinal fluid cells, and period from onset to treatment did not show any significant association with persistent VKH.
ConclusionThe renal function could be a prognostic factor for persistent ocular inflammation in patients with VKH.
Conflict of interestNo
Author 1
Last nameYAMANA
Initials of first name(s)S
CityFukuoka
CountryJapan
Author 2
Last nameHASEGAWA
Initials of first name(s)E
CityFukuoka
CountryJapan
Author 3
Last nameTAKEDA
Initials of first name(s)A
CityFukuoka
CountryJapan
Author 4
Last nameYAWATA
Initials of first name(s)N
CityFukuoka
CountryJapan
Author 5
Last nameSONODA
Initials of first name(s)K
CityFukuoka
CountryJapan