Oral Phospholipidic Curcumin in Juvenile Idiopathic Arthritis-Associated Uveitis
Purpose
To evaluate the efficacy and the safety of the adjunctive treatment with curcumin-phosphatidylcholine complex in children affected by Juvenile idiopathic arthritis (JIA) -associated uveitis.
Methods
In this retrospective, longitudinal study, we treated patients with JIA uveitis and residual low-grade inflammatory activity in the anterior chamber with one tablet of curcumin-phosphatidylcholine complex per day, over a year. Inactivity of uveitis was defined as complete disappearance of flare at the slit-lamp examination and values <10 ph/ms at Laser Flare Meter.
Results
A total of 22 out of 27 patients (81%) achieved inactivity at the end of the study. Five patients (19%) remained stable throughout the follow-up. Overall, the treatment was safe and well tolerated.
Conclusion
Adjunctive therapy with curcumin in patients affected by JIA-associated uveitis improves mild chronic anterior chamber flare and presents a good safety profile. Anterior chamber inflammation should be minimized to avoid sight-threatening complications.
Conflict of interest
No
Author 1
Last name
MISEROCCHI
Initials of first name(s)
E
Department
Department of Ophthalmology, Ospedale San Raffaele Scientific Institute, University Vita-Salute, Mi
City
Milan
Country
Italy
Author 2
Last name
Giuffre
Initials of first name(s)
C
Department
Department of Ophthalmology, Ospedale San Raffaele Scientific Institute, University Vita-Salute, Mi
City
Milan
Country
Italy
Author 3
Last name
Cicinelli
Initials of first name(s)
MV
Department
Department of Ophthalmology, Ospedale San Raffaele Scientific Institute, University Vita-Salute, Mi
City
Milan
Country
Italy
Author 4
Last name
Marchese
Initials of first name(s)
A
Department
Department of Ophthalmology, Ospedale San Raffaele Scientific Institute, University Vita-Salute, Mi
City
Milan
Country
Italy
Author 5
Last name
Modorati
Initials of first name(s)
G
Department
Department of Ophthalmology, Ospedale San Raffaele Scientific Institute, University Vita-Salute, Mi
City
Milan
Country
Italy
Author 6
Last name
Bandello
Initials of first name(s)
F
Department
Department of Ophthalmology, Ospedale San Raffaele Scientific Institute, University Vita-Salute, Mi
City
Milan
Country
Italy
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