Adalimumab in patients with vision threatening uveitis
Purpose
Biologics are rapidly emerging as an effective vision-saving systemic uveitis therapy. The aim of this multicentre retrospective study is to review the outcomes of patients treated with adalimumab.
Methods
A 10-year retrospective chart review of patients with refractory non-infectious uveitis treated with adalimumab was conducted. The main outcome measures were ability to reduce prednisolone dose, ability to control uveitis, final visual acuity and time-to-treatment failure.
Results
46 patients (89 eyes) with uveitis, treated with adalimumab were included in the study. 56.5% male patients and 43.5% female patients and 93.5% bilateral active disease. The most common anatomical uveitis phenotype was pan-uveitis (37.0%). The most common diagnosis was undifferentiated uveitis (41.3%). At their latest review (mean:4.46 years; median 4.40 years), 76.1% patients were able to discontinue corticosteroids, 23.9% patients were able to taper corticosteroids <7.5mg per day. 2.2% patient required a prednisolone dose of 10 mg. The mean visual acuity at the latest follow-up of the worse eye was logMAR 0.42 (SD 0.72), while the mean visual acuity of the better eye was logMAR 0.19 (SD 0.34). 23.6% eyes improved by at least 2 lines, 5.6% eyes deteriorated by 2 or more lines while vision was unchanged in the remaining 70.8% eyes. The time to recurrence was 1 in 12.47 person-years for adalimumab. There were no serious adverse events.
Conclusion
This study highlights the efficacy of adalimumab in patients with vision-threatening non-infectious uveitis, preserving vision and allowing reduction of corticosteroid dose.
Conflict of interest
No
Authors 1
Last name
YANG
Initials of first name(s)
V
Department
Ophthalmology
City
Hobart
Country
Australia
Authors 2
Last name
TANG LEE SAY
Initials of first name(s)
T
Department
Ophthalmology
City
Sydney
Country
Australia
Authors 3
Last name
ZAGORA
Initials of first name(s)
S
Department
Ophthalmology
City
Sydney
Country
Australia
Authors 4
Last name
MCCLUSKEY
Initials of first name(s)
P
Department
Ophthalmology
City
Sydney
Country
Australia
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