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TitleOUTCOMES OF ADALIMUMAB THERAPY IN REFRACTORY PUNCTATE INNER CHOROIDOPATHY AND MULTIFOCAL CHOROIDITIS
PurposeTo evaluate the outcomes of Adalimumab (ADA) in patients with refractory punctate inner choroidopathy (PIC) and multifocal choroiditis (MFC).
MethodsRetrospective review of medical files of patients with refractory PIC/MFC.
Demographic data and clinical characteristics, including LogMAR best-corrected visual acuity (BCVA) were collected. In addition, we recorded the dose of prednisone and types and doses of immunomodulatory therapy (IMT), the number of anti-vascular endothelial growth factor (VEGF) injections for eyes with choroidal neovascularization (CNV), and drug-associated adverse events before and after baseline. The baseline was defined at ADA initiation.
ResultsTen eyes from 7 patients were included (5 with PIC, 2 with MFC). The mean age at presentation was 32.7±8.4 years (Females 57%). Six eyes were being treated with anti-VEGF therapy for CNV. Mean follow-up after baseline was 15.3±15.7 months. Mean LogMAR BCVA was 0.57±1.0 six months prior to baseline, and it remained stable at baseline and at 1,2, and 6 months after baseline (0.42±0.47 at six months;p=0.84). The mean dose of prednisone decreased significantly from 17.3±19.6 mg/day 6 months prior to the baseline to 4.7±3.95 mg/day at the last follow-up after baseline (p=0.03). There was a trend of a decrease in the number of anti-VEGF injections after baseline.
No ADA-related adverse events were noted.
ConclusionAdalimumab therapy of refractory PIC/MFC enabled a significant reduction in prednisone dose with stable BCVA and a good safety profile.
Conflict of interestNo
Authors 1
Last nameSHMUELI
Initials of first name(s)O
DepartmentDepartment of Ophthalmology, Hadassah Medical Center
CityJerusalem
CountryIsrael
Authors 2
Last nameAMER
Initials of first name(s)R
DepartmentDepartment of Ophthalmology, Hadassah Medical Center
CityJerusalem
CountryIsrael