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TitleHLA-B27 AND UVEITIS ASSOCIATED WITH SPONDYLARTHROPATHIES IN A MULTIDISCIPLINARY AUTOIMMUNE DISEASE UNIT: ARE THERE CLINICAL DIFFERENCES BASED ON THE HAPLOTYPE?
PurposeTo compare the clinical characteristics of human leucocyte antigen HLA-B27+ uveitis patients with SpA diagnosis (New York criteria, ASAS) receiving systemic therapies with HLA-B27- uveitis patients.
MethodsWe performed a retrospective and descriptive study by including patients diagnosed with uveitis associated with SpA attending our Multidisciplinary Autoimmune Disease Unit from 2000 to 2020 and compared the clinical profile of patients with uveitis related or not to HLA-B27.
ResultsWe included 73 patients, 78% were HLA-B27+ and 21% were HLA-B27-. HLA-B27- patients were older at diagnosis (43.5±8.9 years vs 39.1±11.6 years, p=0.04). Peripherical articular involvement was more frequent in HLA-B27- patients (44% vs 13%, p=0.01). Uveitis preceded the articular involvement in 75% HLA-B27- patients and in 44% HLA-B27+ (p=0.047). The time since first uveitis flare was longer in the HLA B27+ group: 9.12 years (2.75-12.8) vs 3.56 years (1.34-3.5, p 0.02) in HLA-B27- patients. HLA-B27+ patients showed a higher percentage of bilateral/alternating involvement (61.4% vs 31.2%, p=0.046). Mean recurrence of episodes of uveitis was 3.1 ± 1.78 years in HLA-B27+ patients vs 2.1 ±1.74 years, with no significant difference (p=0.90).
ConclusionUveitis related with positive HLA-B27 debuted at a younger age, with a higher percentage of bilateral/alternating uveitis involvement and a longer period since first uveitis flare. Uveitis onset preceded articular manifestations more frequently in HLA-B27 negative patients.
Conflict of interestNo
Authors 1
Last nameSANTOS
Initials of first name(s)C
DepartmentRHEUMATOLOGY
CityLEÓN
CountrySpain
Authors 2
Last nameSENDINO TENORIO
Initials of first name(s)I
DepartmentOPHTALMOLOGY
CityLEÓN
CountrySpain
Authors 3
Last nameÁLVAREZ CASTRO
Initials of first name(s)C
DepartmentRHEUMATOLOGY
CityLEÓN
CountrySpain
Authors 4
Last nameCORDERO COMA
Initials of first name(s)M
DepartmentOPHTALMOLOGY
CityLEÓN
CountrySpain