HLA-B27 related exudative retinal detachment in ankylosing spondylitis- A case report
Purpose
Report a rare case of HLA-B27 related exudative retinal detachment in ankylosing spondylitis
Methods
A retrospective case report
Results
A 19-year- old female had ankylosing spondylitis. Her condition was not well controlled with elevated CRP and ESR. She had deterioration of vision in the left eye for 3 days, accompanied with photophobia and eye pain. Her best-corrected visual acuity was 20/20 in the right and 20/500 in the left eye. Fundus exam showed bilateral disc edema and patchy exudative retinal detachment at periphery with retinal folding at posterior pole in left eye. FA/ICGA revealed peripheral retinal vasculitis with fluorescein leakage. Broad laboratory testing was pursued and was positive only for HLA-B27. Vision got improved after 6 doses of pulse therapy with methylprednisolone 500mg, associated with marked decreasing sub-foveal fluid. The prednisolone was tapered over the following months. Her visual acuity of the left eye recovered to 20/20 in 1 month.
Conclusion
Although posterior involvement of uveitis associated with ankylosing spondylitis is uncommon; Papillitis, retinal vasculopathy, and even exudative retinal detachment might be seen in poor-control cases.
Conflict of interest
No
Authors 1
Last name
LIN
Initials of first name(s)
HC
Department
Department of ophthalmology, Kaohsiung Medical University Hospital
City
Kaohsiung
Country
Taiwan
Authors 2
Last name
Chiu
Initials of first name(s)
TY
Department
Department of ophthalmology, Kaohsiung Medical University Hospital
City
Kaohsiung
Country
Taiwan
Authors 3
Last name
Kao
Initials of first name(s)
CC
Department
Department of ophthalmology, Kaohsiung Medical University Hospital
City
Kaohsiung
Country
Taiwan
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