| Presentation preference | Oral presentation |
| Title | Expression of matrix metalloproteinases (MMPs) in human intraocular lymphoma |
| Purpose | The purpose of this study is to investigate matrix metalloproteinases (MMPs) expression in human intraocular lymphoma (IOL). |
| Methods | Two enucleated eyes, 7 cell-block samples, and 25 samples of vitreous fluids obtained from patients with IOL who underwent vitrectomy were examined. Immunopathological examinations were performed for detection of MMP-2, MMP-9, and TIMP-4 expressions in enucleated eyes and cell-block samples. Protein concentrations of MMP-2 and MMP-9 were measured using the multiplex bead array assay in vitreous fluids. |
| Results | In the enucleated eye with primary IOL (PIOL), MMP-2 was negative, and MMP-9 and TIMP-4 were positive in lymphoma cells, while in the enucleated eye with secondary IOL (SIOL), all of the molecules were positive. Among cell-block samples with PIOL, the positive rate in lymphoma cells of MMP-2, MMP-9, and TIMP-4 was 75, 100, and 75%, respectively. In cell-block samples with SIOL, the positive rate of MMP-2, MMP-9, and TIMP-4 were all 100%. Intravitreal MMP-2 concentrations were significantly higher in SIOL than in PIOL, while there was no significant difference on MMP-9 concentrations. |
| Conclusion | These results suggest that MMPs may play an important role in the pathogenesis of IOL, especially in the metastasis. |
| Conflict of interest | No |
Authors 1
| Last name | KASE |
| Initials of first name(s) | S |
| Department | Ophthalmology |
| City | Sapporo |
| Country | Japan |
Authors 2
| Last name | Namba |
| Initials of first name(s) | K |
| Department | Ophthalmology |
| City | Sapporo |
| Country | Japan |
Authors 3
| Last name | Suzuki |
| Initials of first name(s) | K |
| Department | Ophthalology |
| City | Sapporo |
| Country | Japan |
Authors 4
| Last name | Fukutsu |
| Initials of first name(s) | K |
| Department | Ophthalmology |
| City | Sapporo |
| Country | Japan |
Authors 5
| Last name | Ishida |
| Initials of first name(s) | S |
| Department | Ophthalmology |
| City | Sapporo |
| Country | Japan |
