| Presentation preference | Oral presentation |
| Title | A four-year trend in full-field electroretinogram (ff-ERG) in patients with Vogt-Koyanagi-Harada disease |
| Purpose | To retrospectively evaluate a four-year trend in ff-ERG and its association with clinical aspects in patients with Vogt-Koyanagi-Harada disease VKHD) followed up since acute onset. |
| Methods | Twenty one consecutive acute VKHD patients (42 eyes), attended at a tertiary center from June 2011 to January 2017, and followed up for at least 48 months, with systematic multimodal and ff-ERG evaluations, were included. Scotopic and photopic ff-ERG parameters at month(M)1, M6, M12 and M48 were analyzed. At M48, eyes were grouped according to the number of abnormal parameters (below the 5th percentile of normal controls): group 1 (none), group 2 (1 to 3) and group 3 (4 to 7). Correlation between ff-ERG results at M48 with clinical and treatment data was pursued. Generalized estimated equations were used for binary ocular data. Interaction P-value, using multivariable models, was used for significant subgroup differences. |
| Results | Subgroups 4-point curves had different behavior for maximum scotopic b amplitude (p=0.005), photopic b amplitude (p=0.024) and flicker (p=0.003). Concerning the other parameters, except for photopic a amplitude, the curves between the groups were parallel (p<0.001). Interval to treatment was shorter in group 1 than in group 2. Fluorescein and indocyanine green angiographies total score at baseline were lower in group 1 than groups 2 and 3. All patients from group 3 had additional immunosuppressive therapy (p<0.001) and were the group with less anterior uveitis relapses (p<0.001). |
| Conclusion | Delay in treatment start and more intense inflammation at baseline seemed to be the main factors to define visual function measured by ff-ERG at a long-term follow-up in VKHD. |
| Conflict of interest | No |
Authors 1
| Last name | YAMAMOTO |
| Initials of first name(s) | JH |
| Department | Ophthalmology, LIM 33, Faculdade de Medicina, Universidade de Sao Paulo |
| City | Sao Paulo |
| Country | Brazil |
Authors 2
| Last name | Souto |
| Initials of first name(s) | FMS |
| Department | Ophthalmology, Faculdade de Medicina, Universidade de Sao Paulo |
| City | Sao Paulo |
| Country | Brazil |
Authors 3
| Last name | Missaka |
| Initials of first name(s) | RFBG |
| Department | Ophthalmology, Faculdade de Medicina, Universidade de Sao Paulo |
| City | Sao Paulo |
| Country | Brazil |
Authors 4
| Last name | Lavezzo |
| Initials of first name(s) | MM |
| Department | Ophthalmology, Faculdade de Medicina, Universidade de Sao Paulo |
| City | Sao Paulo |
| Country | Brazil |
Authors 5
| Last name | Nobrega |
| Initials of first name(s) | PFC |
| Department | Ophthalmology, Faculdade de Medicina, Universidade de Sao Paulo |
| City | Sao Paulo |
| Country | Brazil |
Authors 6
| Last name | Sakata |
| Initials of first name(s) | VM |
| Department | Ophthalmology, Universidade Federal do Parana |
| City | Parana |
| Country | Brazil |
Authors 7
| Last name | Oyamada |
| Initials of first name(s) | MK |
| Department | Ophthalmology, Faculdade de Medicina, Universidade de Sao Paulo |
| City | Sao Paulo |
| Country | Brazil |
Authors 8
| Last name | Hirata |
| Initials of first name(s) | CE |
| Department | Ophthalmology, Faculdade de Medicina, Universidade de Sao Paulo |
| City | Sao Paulo |
| Country | Brazil |
