| Presentation preference | Oral presentation |
| Title | Cyclosporine versus adalimumab added to corticosteroids for Vogt-Koyanagi-Harada disease |
| Purpose | To compare effectiveness of cyclosporine versus adalimumab added to corticosteroids for the treatment of Vogt-Koyanagi-Harada disease. |
| Methods | We randomly assigned 110 patients (27 early-phase and 83 late-phase VKH disease) to receive cyclosporine plus corticosteroids or adalimumab plus corticosteroids in a 1:1 ratio with disease phase as a stratification factor. The primary outcome was the change from baseline in best corrected visual acuity (BCVA) measured as Early Treatment Diabetic Retinopathy Study (ETDRS) score at week 26. The minimal clinically important difference for changes in ETDRS score is -7 letters, which constituted the margin of non-inferiority for cyclosporine plus corticosteroids. We analyzed the data from early and late-phase VKH patients as two separate studies. |
| Results | In early-phase VKH disease, the primary outcome was 12.1 letters (95% CI, 8.5 to 15.7) in the cyclosporine-corticosteroids group and 13.0 letters (95% CI, 9.1 to 16.9) in the adalimumab-corticosteroids group (difference, -0.8; 95% CI, -6.1 to 4.5). In late-phase VKH disease, the primary outcome was 7.2 letters (95% CI, 3.4 to 11.0) in the cyclosporine-corticosteroids group and 1.5 letters (95% CI, -2.3 to 5.3) in the adalimumab-corticosteroids (difference, 5.7; 95% CI, 0.2 to 11.2). |
| Conclusion | Cyclosporine plus corticosteroids was non-inferior to adalimumab plus corticosteroids on the basis of primary results of visual acuity at 26 weeks, regardless of early or late phase. |
| Conflict of interest | No |
Authors 1
| Last name | ZHONG |
| Initials of first name(s) | Z |
| Department | The First Affiliated Hospital of Chongqing Medical University |
| City | Chongqing |
| Country | China |
Authors 2
| Last name | Dai |
| Initials of first name(s) | L |
| Department | The First Affiliated Hospital of Chongqing Medical University |
| City | Chongqing |
| Country | China |
Authors 3
| Last name | Wu |
| Initials of first name(s) | Q |
| Department | The First Affiliated Hospital of Chongqing Medical University |
| City | Chongqing |
| Country | China |
Authors 4
| Last name | Gao |
| Initials of first name(s) | Y |
| Department | The First Affiliated Hospital of Chongqing Medical University |
| City | Chongqing |
| Country | China |
Authors 5
| Last name | Pu |
| Initials of first name(s) | Y |
| Department | The First Affiliated Hospital of Chongqing Medical University |
| City | Chongqing |
| Country | China |
Authors 6
| Last name | Su |
| Initials of first name(s) | G |
| Department | The First Affiliated Hospital of Chongqing Medical University |
| City | Chongqing |
| Country | China |
Authors 7
| Last name | Lu |
| Initials of first name(s) | X |
| Department | The First Affiliated Hospital of Chongqing Medical University |
| City | Chongqing |
| Country | China |
Authors 8
| Last name | Zhang |
| Initials of first name(s) | F |
| Department | The First Affiliated Hospital of Chongqing Medical University |
| City | Chongqing |
| Country | China |
Authors 9
| Last name | Tang |
| Initials of first name(s) | C |
| Department | The First Affiliated Hospital of Chongqing Medical University |
| City | Chongqing |
| Country | China |
Authors 10
| Last name | Yang |
| Initials of first name(s) | P |
| Department | The First Affiliated Hospital of Chongqing Medical University |
| City | Chongqing |
| Country | China |
