| Presentation preference | Poster presentation |
| Title | Steroid-sparing effect of Adalimumab monotherapy in non-infectious uveitis |
| Purpose | To evaluate the steroid-sparing effect of adalimumab (ADA) monotherapy in non-infectious uveitis. |
| Methods | This study included patients with non-infectious uveitis who required prednisolone ≥ 5 mg/day for controlling inflammation and were treated with ADA monotherapy. For patients who experienced uveitis flare-ups during steroid tapering, methotrexate was added concomitantly with ADA. We also assessed the efficacy of MTX as well. |
| Results | The study included 38 patients (17 females). The most common disease was Vogt-Koyanagi-Harada (VKH) disease (11 patients), followed by retinal vasculitis (9 patients) and Behçet's disease (7 patients). The mean systemic steroid dose before ADA induction was 15.2 mg/day. While 30 patients could taper off steroids, 8 (21.1%) patients relapsed during steroid reduction. VKH disease was the most common relapse in 5 patients, followed by Behçet's disease, retinal vasculitis, and posterior scleritis in 1 patient each. Six out of 8 relapsed patients received concomitant MTX, and three were able to wean off steroids. |
| Conclusion | About 80% of the patients were able to taper off steroids with the ADA monoterapy. In cases that relapse by ADA monotherapy, VKH disease was the most common. However, the addition of MTX to ADA treatment enable to taper off steroid in half of these cases. |
| Conflict of interest | No |
Authors 1
| Last name | HARADA |
| Initials of first name(s) | Y |
| Department | Hiroshima University |
| City | Hiroshima |
| Country | Japan |
Authors 2
| Last name | Hiyama |
| Initials of first name(s) | T |
| Department | Hiroshima University |
| City | Hiroshima |
| Country | Japan |
Authors 3
| Last name | Sada |
| Initials of first name(s) | I |
| Department | Hiroshima University |
| City | Hiroshima |
| Country | Japan |
Authors 4
| Last name | Kiuchi |
| Initials of first name(s) | Y |
| Department | Hiroshima Univerisity |
| City | Hiroshima |
| Country | Japan |
