| Presentation preference | Oral presentation |
| Title | Cohort comparative analysis of antimetabolites and biologic drugs on retinal and choroidal features in Birdshot chorioretinopathy |
| Accept poster if oral is not possible ? | Yes |
| Purpose | To assess the effect of antimetabolites (mycophenolate mofetil, azathioprine) and biologics (adalimumab, infliximab) on retinal and choroidal inflammation in Birdshot chorioretinopathy (BSCR). |
| Methods | Data on drugs and concerning the vitreous, retina (papillitis, macular edema and vasculitis) and choroid (dark dots) at baseline and after 6 months were retrospectively collected from 60 eyes of 30 patients with BSCR (14 female and 16 male) followed at the Ocular Immunology Unit of Reggio Emilia. Descriptive analyses and logistic regression were performed per eye, considering cluster of paired eyes per patient. |
| Results | Retinal response is more frequent in eyes treated with biologics (83%) compared to antimetabolites (23%), while choroidal response is more frequent with antimetabolites (96%) than biologics (50%). Biologics strongly decrease the risk of vasculitis by 99% compared to antimetabolites (OR=0.07; 95%CI 0.01-0.79). Vitreitis, papillitis and macular edema persist (16%, 18% and 40% respectively) in patients treated with antimetabolites, while with biologics 100% have a complete remission. Antimetabolites show a higher response rate than biologics on dark dots (OR=11.00;95%CI 1.26-98.75). |
| Conclusion | Biological agents appear to be more effective in controlling inflammation of the retina, whereas antimetabolites on the choroid. These results highlight the need to explore the potential benefits of administering both drug types in the early stage of treatment. |
| Conflict of interest | No |
1
| Last name | DE SIMONE |
| Initials of first name(s) | L |
| Department | Ocular Immunology Unit, Azienda USL-IRCCS di Reggio Emilia |
| City | Reggio Emilia |
| Country | Italy |
2
| Last name | CECCARELLI |
| Initials of first name(s) | F |
| Department | Ophthalmology Unit, Department of Experimental Medicine, University of Rome "Tor Vergata" |
| City | Rome |
| Country | Italy |
3
| Last name | VICENTINI |
| Initials of first name(s) | M |
| Department | Epidemiology Unit, Azienda USL-IRCCS di Reggio Emilia |
| City | Reggio Emilia |
| Country | Italy |
4
| Last name | BONVICINI |
| Initials of first name(s) | L |
| Department | Epidemiology Unit, Azienda USL-IRCCS di Reggio Emilia |
| City | Reggio Emilia |
| Country | Italy |
5
| Last name | FERRARO |
| Initials of first name(s) | V |
| Department | Department of Biomedical Sciences, Humanitas University, Pieve Emanuele |
| City | Milan |
| Country | Italy |
6
| Last name | BOLLETTA |
| Initials of first name(s) | E |
| Department | Ocular Immunology Unit, Azienda USL-IRCCS di Reggio Emilia |
| City | Reggio Emilia |
| Country | Italy |
7
| Last name | GOZZI |
| Initials of first name(s) | F |
| Department | Ocular Immunology Unit, Azienda USL-IRCCS di Reggio Emilia |
| City | Reggio Emilia |
| Country | Italy |
8
| Last name | GENTILE |
| Initials of first name(s) | P |
| Department | Ocular Immunology Unit, Azienda USL-IRCCS di Reggio Emilia |
| City | Reggio Emilia |
| Country | Italy |
9
| Last name | CIMINO |
| Initials of first name(s) | L |
| Department | Ocular Immunology Unit, Azienda USL-IRCCS di Reggio Emilia |
| City | Reggio Emilia |
| Country | Italy |
