| Presentation preference | Poster presentation |
| Title | Efficacy and Safety of Biosimilar Adalimumab (biADA, Hyrimoz®) in Behcet’s Uveitis |
| Accept poster if oral is not possible ? | Yes |
| Purpose | To evaluate the efficacy and safety of biosimilar adalimumab (biADA, Hyrimoz®) in patients with Behçet’s uveitis in Thailand, an endemic area for tuberculosis (TB). |
| Methods | We conducted a retrospective study on Behçet’s uveitis patients who failed conventional treatments and were anti-TNF naïve. The primary endpoint was improvement in logMAR best-corrected visual acuity (BCVA), with secondary endpoints including changes in central subfield thickness (CST), prednisolone dosage, ocular inflammation, and adverse reactions at six months following biosimilar adalimumab (biADA, Hyrimoz®) treatment. |
| Results | A total of 26 eyes from 14 patients were included, with a mean follow-up duration of 190 days. After 6 months of treatment with biosimilar adalimumab (biADA), significant improvements were observed in logMAR BCVA (from 0.99 to 0.78, P = 0.032), CST (from 301.09 µm to 258.41 µm, P = 0.009), and prednisolone dosage (from 22.5 mg/day to 3.7 mg/day, P < 0.0001). Additionally, oral prednisolone dosage was significantly reduced within one month of biADA initiation, with half of the patients able to discontinue oral prednisolone entirely within 50 days. However, one patient developed active pulmonary tuberculosis after 4 months of biADA treatment, and another patient developed vitiligo on the skin. |
| Conclusion | Biosimilar adalimumab (biADA, Hyrimoz®) effectively improved visual outcomes, reduced ocular inflammation, and lowered corticosteroid use in Behçet’s uveitis. Careful monitoring for adverse events, like tuberculosis reactivation, is crucial in endemic areas. It offers an affordable alternative for managing Behçet’s uveitis in resource-limited settings. |
| Conflict of interest | No |
1
| Last name | PIYAPHINYOPHAP |
| Initials of first name(s) | Chak |
| Department | Department of Ophthalmology, Faculty of Medicine, Khon Kaen University |
| City | Khonkaen |
| Country | Thailand |
2
| Last name | LAOVIROJJANAKUL |
| Initials of first name(s) | Wipa |
| Department | Department of Ophthalmology, Faculty of Medicine, Khon Kaen University |
| City | Khonkaen |
| Country | Thailand |
