| Presentation preference | Poster presentation |
| Title | Periocular vs. Intravitreal Steroids for Uveitic Macular Edema: A Real-World POINT Study |
| Accept poster if oral is not possible ? | No |
| Purpose | To study the effects of regional corticosteroid injections of periocular triamcinolone acetonide (PTA), intravitreal triamcinolone acetonide (ITA), and intravitreal dexamethasone implant (IDI) on uveitic macular edema (ME). |
| Methods | Retrospective cohort study of patients with non-infectious uveitis with ME comparing three treatment groups: PTA-40mg, ITA-4mg, and IDI-0.7mg. Analyses included change in central subfield thickness (CST), best-corrected visual acuity (VA), and intraocular pressure (IOP) at weeks 8 and 24, as well as incidence of additional injection over one year. |
| Results | Study included 140 eyes of 102 patients. At week-8, CST and VA improved within all groups (p<0.001), and IOP was elevated within all groups (p=0.003, 0.015, 0.046, for PTA, ITA, IDI, respectively). At week-24, CST remained improved within all groups (p<0.001); VA remained improved only with PTA and IDI (p<0.001, p=0.013 for PTA, IDI, respectively), but not with ITA; and IOP no longer remained elevated within any group. At week-8, comparison across groups showed CST had greater improvement with IDI (p=0.007), but there were no differences in VA and IOP. At week-24, there were no differences across groups in CST, VA, or IOP. Over one year, 51.4% of eyes were treated with additional injections. The IDI group was more likely to be treated with additional injections (p=0.038). |
| Conclusion | PTA, ITA, and IDI are effective in treating uveitic ME with sustained improvement in CST and VA and transient elevation of IOP. IDI showed greater improvement in CST at week-8 and was more likely to be treated with additional injections over one year. |
| Conflict of interest | No |
1
| Last name | HOSSAIN |
| Initials of first name(s) | HA |
| Department | Department of Ophthalmology, Emory University School of Medicine |
| City | Atlanta, Georgia |
| Country | United States |
2
| Last name | SONUGA |
| Initials of first name(s) | A |
| Department | Department of Ophthalmology, Emory University School of Medicine |
| City | Atlanta, Georgia |
| Country | United States |
3
| Last name | DODD |
| Initials of first name(s) | M |
| Department | Department of Ophthalmology, Emory University School of Medicine |
| City | Atlanta, Georgia |
| Country | United States |
4
| Last name | OU |
| Initials of first name(s) | X |
| Department | Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University |
| City | Atlanta, Georgia |
| Country | United States |
5
| Last name | CUI |
| Initials of first name(s) | X |
| Department | Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University |
| City | Atlanta, Georgia |
| Country | United States |
6
| Last name | O'KEEFE |
| Initials of first name(s) | GD |
| Department | Department of Ophthalmology, Emory University School of Medicine |
| City | Atlanta, Georgia |
| Country | United States |
