| Presentation preference | Oral presentation |
| Title | Killer cell Immunoglobulin-like Receptors and ligands in patients with CMV-Anterior Uveitis |
| Accept poster if oral is not possible ? | Yes |
| Purpose | Cytomegalovirus Anterior Uveitis（CMV-AU）manifests in immunocompetent individuals of which the mechanisms are unknown. In this study, we have investigated the role of NK cells in CMV-AU. Important determinants that differentiate human NK responses are the Killer Cell Immunoglobulin-like Receptors (KIR) and their ligands, HLA class I subgroups. Combinations of polymorphisms of KIR and HLA are known to be associated with resistance against virus infection and progression. |
| Methods | KIR ligands in 118 Chinese Singaporean CMV-AU cases were determined using Next Generation Sequencing (NGS). KIR genotypes were determined using a PCR-SSP method. The data was compared against the profiles of the healthy Chinese Singaporean population. |
| Results | Among HLA-B Bw4 allele groups (80Ile, 80Thr), the frequency of the 80Ile allele group was significantly increased and the frequency of 80Thr allele group was significantly lower in CMV-AU patients compared to those in healthy controls. No difference was observed in the frequencies of ligands for KIR2DL1/2DL3 and the group A haplotype. |
| Conclusion | Genetic profiles of KIRs and their ligands in CMV-AU contrast to the KIR/HLA associations reported previously for symptomatic systemic primary CMV infection, implying that the immunological mechanisms against CMV are likely distinct. |
| Conflict of interest | No |
Author 1
| Last name | YAWATA |
| Initials of first name(s) | N |
| City | Fukuoka |
| Country | Japan |
Author 2
| Last name | Siak |
| Initials of first name(s) | J |
| Department | Singapore Eye Research Institute, Singapore National Eye Centre, National University of Singapore |
| City | Singapore |
| Country | Singapore |
Author 3
| Last name | Chee |
| Initials of first name(s) | SP |
| Department | Singapore Eye Research Institute, Singapore National Eye Centre, National University of Singapore |
| City | Singapore |
| Country | Singapore |
Author 4
| Last name | Kawano |
| Initials of first name(s) | Y |
| Department | Fukuoka Dental College |
| City | Fukuoka |
| Country | Japan |
Author 5
| Last name | Yawata |
| Initials of first name(s) | M |
| Department | National University of Singapore |
| City | Singapore |
| Country | Singapore |
Author 6
| Last name | Sonoda |
| Initials of first name(s) | KH |
| Department | Kyushu University |
| City | Fukuoka |
| Country | Japan |
