| Presentation preference | Poster presentation |
| Title | Comparative diagnostic performance of ultrawide field imaging, retinal nerve fiber layer and Spectralis and Optos Fluorescein Angiography in the detection of Optic Disc Swelling in uveitis |
| Purpose | To compare the sensitivity and specificity of ultrawide field fundus photographs (UWF-FP), retinal nerve fiber layer (RNFL) thickness on optical coherence tomography and fluorescein angiography (FA) performed with two imaging platforms in the diagnosis of Optic Disc Swelling (ODW) in uveitis. |
| Methods | Retrospective file review of all consecutive uveitic patients seen at a tertiary care unit during 2022 who underwent UWF-FP, RNFL and FA with both Optos Optomap and Heidelberg Spectralis on the same date. Two masked specialists evaluated the presence of ODW (ie. gold standard) based on fundus examination, UWF-FP, RNFL thickness and FA. The performance of each test was compared to this diagnostic gold standard. |
| Results | 101 eyes of 59 patients with uveitis were included. 56 eyes (55.4%) presented ODW. The sensitivity and specificity of UWF-FP were 24.5% and 92.3%. With an RNFL thickness of <200 µm as reference, the RNFL global (G) sensitivity and specificity were 5.8% and 100%. The supratemporal area (ST) proved to be the most sensitive (23%) with a similar specificity (97.7%). Regarding FA, the sensitivity of the two platforms was 100%. However, the specificity was better with Spectralis (97.8%) versus 68.2% with Optos (p<0.05). Overall, the AUROC for discriminating ODW eyes was the highest on FA performed with Spectralis (0.99) followed by Optos (0.84), RNFL ST (0.60), UWF-FP (0.59) and RNFL G (0.53). |
| Conclusion | The clinical utility of UWF-FP and RNFL is limited in diagnosing ODW. In contrast, FA, in particular the platform Spectralis, showed the best specificity and sensitivity in detecting uveitic ODW. |
| Conflict of interest | No |
Authors 1
| Last name | BOURDIN |
| Initials of first name(s) | A |
| Department | Department of Ophthalmology, Pitié Salpêtrière University Hospital, Sorbonne Université |
| City | Paris |
| Country | France |
Authors 2
| Last name | FLOREZ-ESPARZA |
| Initials of first name(s) | G |
| Department | Neuroscience (NEUROS) Research Group, Neurovitae Research Center, Universidad Del Rosario |
| City | Bogotá |
| Country | Colombia |
Authors 3
| Last name | DE-LA-TORRE |
| Initials of first name(s) | A |
| Department | Neuroscience (NEUROS) Research Group, Neurovitae Research Center, Universidad Del Rosario |
| City | Bogotá |
| Country | Colombia |
Authors 4
| Last name | BODAGHI |
| Initials of first name(s) | B |
| Department | Department of Ophthalmology, Pitié Salpêtrière University Hospital, Sorbonne Université |
| City | Paris |
| Country | France |
Authors 5
| Last name | TOUHAMI |
| Initials of first name(s) | S |
| Department | Department of Ophthalmology, Pitié Salpêtrière University Hospital, Sorbonne Université |
| City | Paris |
| Country | France |
