| Presentation preference | Poster presentation |
| Title | Parinaud's Oculoglandular Syndrome: A Case Series |
| Accept poster if oral is not possible ? | Yes |
| Purpose | To characterize cases of sporotrichosis presenting as Parinaud's oculoglandular syndrome (POS). |
| Methods | Retrospective review of medical charts/laboratory results of patients with POS presenting at our emergency eye care facility. |
| Results | Ten patients with POS were identified, aged 8-47 years, with four females. Most presented with persistent conjunctival hyperemia/mucoid discharge. These had been treated with topical corticosteroids/antibiotics/saline irrigation, with no improvement. One patient had a two-month history of progressive unilateral cervical/preauricular lymphadenopathy, concerning for lymphoma. He was then hospitalized and referred for ophthalmology assessment. Examination revealed unilateral mild conjunctival hyperemia, marked follicular reaction, tarsal conjunctival granulomas and ipsilateral preauricular lymphadenopathy in all cases. Eight patients showed mucoid discharge, and only one had bulbar conjunctival granulomas. All patients reported contact with domestic cats. Six had been scratched by cats that exhibited skin lesions suggestive of sporotrichosis. Conjunctival scrapings were taken for microbial culture, and itraconazole 100mg bid was initiated for all cases. After one month of treatment, all patients had symptomatic improvement, although granulomas could be found until after 16 weeks of therapy. Sporothrix sp. was cultured from 4/10 cases (40%). |
| Conclusion | Sporotrichosis is reemerging in Brazil, representing the leading etiology of POS, in contrast to Bartonella. Early clinical presentation may overlap with viral conjunctivitis, complicating diagnosis. Definitive fungal isolation is by culture on Sabouraud agar, and antifungal therapy is often maintained for a long period, until two weeks after resolution of granulomas. |
| Conflict of interest | No |
1
| Last name | FREIRE |
| Initials of first name(s) | BCC |
| Department | Hospital São Geraldo/HC da Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil |
| City | BELO HORIZONTE |
| Country | Brazil |
2
| Last name | GUIMARÃES |
| Initials of first name(s) | GB |
| Department | Hospital São Geraldo/HC da Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil |
| City | Belo Horizonte |
| Country | Brazil |
3
| Last name | VIANA |
| Initials of first name(s) | LE |
| Department | Hospital São Geraldo/HC da Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil |
| City | Belo Horizonte |
| Country | Brazil |
4
| Last name | Otoni |
| Initials of first name(s) | YFM |
| Department | Hospital São Geraldo/HC da Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil |
| City | Belo Horizonte |
| Country | Brazil |
5
| Last name | VASCONCELOS-SANTOS |
| Initials of first name(s) | DV |
| Department | Hospital São Geraldo/HC da Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil 2 Fac |
| City | Belo Horizonte |
| Country | Brazil |
