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This abstract is assigned to session Free Papers : Posters on Display - Series 201-2..

Presentation preference	Poster presentation
Title	Bacillary Layer Detachment in Acute Vogt-Koyanagi-Harada Disease: An Early Predictor of Long-term Complications
Accept poster if oral is not possible ?	Yes

Purpose	To evaluate the presence of bacillary layer detachment (BALAD) at presentation in patients with Vogt-Koyanagi-Harada disease (VKHD) as a predictor of long-term structural and functional outcomes.
Methods	Retrospective cohort study. Thirty-three VKHD patients (66 eyes) were followed over 12 months under clinical and predefined therapeutic protocols. Clinical and multimodal data were collected at baseline and at months (M) 1, 3, 6, 9, and 12. Spectral-domain optical coherence tomography (SD-OCT)-based structural findings were correlated with subretinal fibrosis (SRF), sunset glow fundus (SGF), and atrophic nummular lesions (ANL) at M12. Univariate, bivariate, and multivariate analyses were used. The main outcome measures were SD-OCT retinal alterations during study period; risk factors for SRF, SGF, and ANL at M12.
Results	At baseline, 96.4% of 56 eyes had serous retinal detachments (SRD) and 48.2% had BALAD; at M1, 42.4% had SRD and 6.1% had BALAD. 9.1%, 4.5%, and 3.0% of eyes had SRD at M3, M6, and M9, respectively. Bivariate analysis showed that early BALAD was related with a large SRD area (p=0.036) at presentation and with both SRF (p<0.001) and SGF (p=0.008) at M12. Multivariate regression analysis showed that early BALAD (OR, 12.04; p=0.011) and a longer interval to treatment start (32 vs 17 days; OR, 1.17; p=0.004) were independent risk factor for SRF at M12, while early BALAD (OR, 14.78; p=0.002) and anterior uveitis recurrences (OR, 30.94; p=0.022) were independent risk factor for SGF. Late ANL was not linked to BALAD at presentation.
Conclusion	BALAD at presentation in acute VKHD was an early predictor of SRF and SGF at 12-month follow-up.
Conflict of interest	No

1

Last name	GUSMÃO
Initials of first name(s)	CC
Department	Department of Ophthalmology, Universidade de São Paulo, Faculdade de Medicina, LIM 33
City	São Paulo
Country	Brazil

2

Last name	MISSAKA
Initials of first name(s)	RFBG
Department	Department of Ophthalmology, Universidade de São Paulo, Faculdade de Medicina, LIM 33
City	São Paulo
Country	Brazil

3

Last name	GOLDBAUM
Initials of first name(s)	M
Department	Department of Ophthalmology, Universidade de São Paulo, Faculdade de Medicina, LIM 33
City	São Paulo
Country	Brazil

4

Last name	MACHADO
Initials of first name(s)	CG
Department	Department of Ophthalmology, Universidade de São Paulo, Faculdade de Medicina, LIM 33
City	São Paulo
Country	Brazil

5

Last name	CUNNINGHAM JR
Initials of first name(s)	E
Department	Department of Ophthalmology, Universidade de São Paulo, Faculdade de Medicina, LIM 33
City	São Paulo
Country	Brazil

6

Last name	SOUTO
Initials of first name(s)	FM
Department	Department of Ophthalmology, Universidade de São Paulo, Faculdade de Medicina, LIM 33
City	São Paulo
Country	Brazil

7

Last name	NÓBREGA
Initials of first name(s)	PFC
Department	Department of Ophthalmology, Universidade de São Paulo, Faculdade de Medicina, LIM 33
City	São Paulo
Country	Brazil

8

Last name	LAVEZZO
Initials of first name(s)	MM
Department	Department of Ophthalmology, Universidade de São Paulo, Faculdade de Medicina, LIM 33
City	São Paulo
Country	Brazil

9

Last name	OYAMADA
Initials of first name(s)	MK
Department	Department of Ophthalmology, Universidade de São Paulo, Faculdade de Medicina, LIM 33
City	São Paulo
Country	Brazil

10

Last name	HIRATA
Initials of first name(s)	CE
Department	Department of Ophthalmology, Universidade de São Paulo, Faculdade de Medicina, LIM 33
City	São Paulo
Country	Brazil

11

Last name	YAMAMOTO
Initials of first name(s)	JH
Department	Department of Ophthalmology, Universidade de São Paulo, Faculdade de Medicina, LIM 33
City	São Paulo
Country	Brazil