| Presentation preference | Oral presentation |
| Title | Dietary intake of whale oil containing ω-3 long-chain polyunsaturated fatty acids attenuates choroidal neovascularization in mice |
| Accept poster if oral is not possible ? | Yes |
| Purpose | Since anti-vascular endothelial growth factor (VEGF) therapy is available for the regression of choroidal neovascularization (CNV), it does not work for the pathophysiology of Age-related macular degeneration (AMD), so a cure is increasingly demanded. Whale oil promotes various bodily functions, such as anti-inflammatory effects for cardiovascular disease, but its physiological mechanisms are still unclarified. Here, we examined the effects of whale oil on a mouse model of AMD. |
| Methods | C57BL/6 mice were given to a diet that was either supplemented with whale oil or free of ω-3 long-chain polyunsaturated fatty acids (LCPUFAs). Mice were subjected to laser photocoagulation 2 weeks after the diet respectively. |
| Results | The area of CNV measured in choroidal flat-mount preparations at 7 days after laser photocoagulation was significantly smaller in mice fed whale oil compared with control mice free of ω-3 LCPUFAs. The plasma concentrations of ω-3 LCPUFAs were higher, whereas those of ω-6 LCPUFAs were lower in mice fed the diet containing whale oil than in those fed the control diet. The concentrations of various inflammatory cytokines and chemokines in the retina or choroid at 3 or 7 days after CNV induction differed between the two groups of mice. The concentration of VEGF was decreased in the retina but increased in the choroid at 7 or 3 days after photocoagulation, respectively. |
| Conclusion | Dietary intake of whale oil containing ω-3 LCPUFAs attenuated CNV in association with changes in inflammatory mediator levels and VEGF expression in the retina and choroid of mice, and it, therefore, warrants further study as a means to protect against AMD in humans. |
| Conflict of interest | No |
1
| Last name | YANAI |
| Initials of first name(s) | R |
| Department | Ophthalmology |
| City | Tokushima |
| Country | Japan |
2
| Last name | Yasunaga |
| Initials of first name(s) | G |
| Department | Institute of Cetacean Research |
| City | Chuo-ku |
| Country | Japan |
3
| Last name | Tsuji |
| Initials of first name(s) | S |
| Department | Pharmacology |
| City | Ube |
| Country | Japan |
4
| Last name | Honda |
| Initials of first name(s) | T |
| Department | Pharmacology |
| City | Ube |
| Country | Japan |
5
| Last name | Iwata |
| Initials of first name(s) | A |
| Department | Yamaguchi Prefectural Industrial Technology Institute |
| City | Ube |
| Country | Japan |
6
| Last name | Miyagawa |
| Initials of first name(s) | e |
| Department | Yamaguchi Prefectural Industrial Technology Institute |
| City | Ube |
| Country | Japan |
7
| Last name | Kishimoto |
| Initials of first name(s) | M |
| Department | Faculty of Economics |
| City | Shimonoseki |
| Country | Japan |
8
| Last name | Sakai |
| Initials of first name(s) | H |
| Department | Institute of Cetacean Research |
| City | Chuo-ku |
| Country | Japan |
9
| Last name | Fujise |
| Initials of first name(s) | Y |
| Department | Institute of Cetacean Research |
| City | Chuo-ku |
| Country | Japan |
10
| Last name | Asagiri |
| Initials of first name(s) | M |
| Department | Pharmacology |
| City | Ube |
| Country | Japan |
11
| Last name | Mitamura |
| Initials of first name(s) | Y |
| Department | Ophthalmology |
| City | Tokushima |
| Country | Japan |
