| Presentation preference | Poster presentation |
| Title | The risk assessment of uveitis after monkeypox diagnosis: A multicenter population-based study |
| Accept poster if oral is not possible ? | Yes |
| Purpose | Human monkeypox (MPOX) infection is attributed to the MPOX virus. While details on ophthalmologic manifestations have been limited, some case reports of uveitis have also been documented. However, uveitis has not been extensively documented among MPOX patients. Therefore, we conducted a population‐based study utilizing the TriNetX electronic health registry database. |
| Methods | Retrospective cohort study used the TriNetX database and recruited those with and without MPOX diagnosis from January 1, 2016, to December 31, 2023. The non‐MPOX cohort consisted of randomly selected control patients, including age, gender, ethnicity, race, relevant comorbidities, previous medications, and the inflammatory marker C‐reactive protein. Statistical analysis on uveitis risk included hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated over 8 years (2016–2023). A separate analysis of the risk of uveitis among MPOX patients aged 20 years and older was also conducted. |
| Results | A total of 5449 MPOX patients of all ages (25.45% female; mean age 35.17 ± 15.70 years) and 5449 propensity‐matched non‐MPOX comparators (23.97% female; mean age 35.30 ± 15.91 years) were recruited. For both the overall MPOX patient population and the adult MPOX patients, the risk of uveitis was significantly higher. This increased risk mainly happened in patients with anterior uveitis. Specifically, the HR for uveitis in all MPOX patients was 2.59. Among MPOX patients aged 20 years or older, the HR for uveitis was 2.14. |
| Conclusion | There is a notable association between new‐onset uveitis and patients with MPOX. Our real‐world findings underscore the importance of being aware of the potential risk of anterior uveitis. |
| Conflict of interest | No |
1
| Last name | LIN |
| Initials of first name(s) | CJ |
| Department | Department of Ophthalmology, China Medical University Hospital, Taiwan |
| City | Taichung |
| Country | Taiwan |
2
| Last name | HSU |
| Initials of first name(s) | A |
| Department | Department of Ophthalmology, China Medical University Hospital, Taiwan |
| City | Taichung |
| Country | Taiwan |
