| Presentation preference | Oral presentation |
| Title | Simultaneous-onset Vogt-Koyanagi-Harada (VKH) disease and secondary glaucoma in a Monozygotic Twin pair – A 10-Year Follow-Up of Cases. |
| Accept poster if oral is not possible ? | Yes |
| Purpose | To describe the complex parallel clinical courses, including initial presentation and onset, diagnosis, investigations and long-term management over ten years of these rare cases of simultaneous-onset VKH and its ophthalmic sequelae in a monozygotic twin pair. |
| Methods | Detailed examination of electronic patient records, dating from initial presentation in December 2014 to present. |
| Results | Both twins were 22 years old at the time of presentation. Diagnostic criteria for VKH were met in both cases. Case 1 presented typically with panuveitis and multifocal choroiditis. Case 2 presented 2 months later with granulomatous inflammation and associated acute synechial angle closure.
Both patients have been treated extensively for secondary uveitic glaucoma; Case 1 with bilateral Baerveldt tubes and Case 2 with YAG peripheral iridotomies, a Trabeculectomy in one eye and Baerveldt tube in the second eye. Both patients were commenced on immunosuppression with Azathioprine to control ocular inflammation. |
| Conclusion | Familial cases of VKH are rare and there are exceptionally few cases in the literature of presentation in monozygotic twins. We present a detailed 10-year follow-up of near simultaneous onset VKH, including the diagnostic process, HLA typing, immunosuppression and its response, and the management of secondary glaucoma and ophthalmic sequelae. |
| Conflict of interest | No |
1
| Last name | XU |
| Initials of first name(s) | Z.Y. |
| Department | University Hospitals Birmingham NHS Foundation Trust |
| City | Birmingham |
| Country | United Kingdom |
2
| Last name | Chan |
| Initials of first name(s) | E. |
| Department | University Hospitals Birmingham NHS Foundation Trust |
| City | Birmingham |
| Country | United Kingdom |
3
| Last name | Elsheikh |
| Initials of first name(s) | S. |
| Department | University Hospitals Birmingham NHS Foundation Trust |
| City | Birmingham |
| Country | United Kingdom |
4
| Last name | Balasubramaniam |
| Initials of first name(s) | B. |
| Department | University Hospitals Birmingham NHS Foundation Trust |
| City | Birmingham |
| Country | United Kingdom |
5
| Last name | Agorogiannis |
| Initials of first name(s) | G. |
| Department | University Hospitals Birmingham NHS Foundation Trust |
| City | Birmingham |
| Country | United Kingdom |
6
| Last name | Skew |
| Initials of first name(s) | H. |
| Department | University Hospitals Birmingham NHS Foundation Trust |
| City | Birmingham |
| Country | United Kingdom |
7
| Last name | Denniston |
| Initials of first name(s) | A. |
| Department | University Hospitals Birmingham NHS Foundation Trust |
| City | Birmingham |
| Country | United Kingdom |
8
| Last name | Patil |
| Initials of first name(s) | A. |
| Department | University Hospitals Birmingham NHS Foundation Trust |
| City | Birmingham |
| Country | United Kingdom |
