| Presentation preference | Poster presentation |
| Title | A Computable Phenotype for HSV Anterior Uveitis: Operationalizing the SUN Classification Criteria employing the OMOP Common Data Model |
| Accept poster if oral is not possible ? | Yes |
| Purpose | Data models can enhance observational research for rare diseases like uveitis. This study operationalized the Standardization of Uveitis Nomenclature (SUN) classification criteria for herpes simplex virus (HSV) anterior uveitis into the Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM). |
| Methods | Using the Observational Health Data Sciences and Informatics (OHDSI) ATLAS tool, we constructed a computable phenotype, applied it to two electronic health records (EHR) systems for internal validation, and to Optum’s Clinformatics® claims database for external validation. |
| Results | In EHR manual chart reviews, we identified 5,404 and 38 patients at two sites, achieving 70% and 90% accuracy, respectively, in a randomized validation sample. From the claims database, 10,858 (2.7%) patients met all criteria, consistent with previous literature. The most discriminatory inclusion criterion was a history of HSV keratitis. |
| Conclusion | Our results indicate that OMOP can accurately identify HSV anterior uveitis, suggesting potential utility for operationalizing other uveitis subtypes in observational research. |
| Conflict of interest | No |
1
| Last name | TOY |
| Initials of first name(s) | B |
| Department | USC Roski Eye Institute |
| City | Los Angeles |
| Country | United States |
2
| Last name | Armbrust |
| Initials of first name(s) | K |
| Department | Minneapolis VA Health Care System, University of Minnesota |
| City | Minneapolis |
| Country | United States |
3
| Last name | Kim |
| Initials of first name(s) | A |
| Department | USC Roski Eye Institute |
| City | Los Angeles |
| Country | United States |
4
| Last name | Lee |
| Initials of first name(s) | E |
| Department | USC Roski Eye Institute |
| City | Los Angeles |
| Country | United States |
5
| Last name | Huang |
| Initials of first name(s) | L |
| Department | UCSD Shiley Eye Institute |
| City | San Diego |
| Country | United States |
