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TitleManagement dilemma: QuantiFERON reversion in a young man with panuveitis
Accept poster if oral is not possible ?Yes
PurposeTo present a case who had panuveitis in the right eye and QuantiFERON positive at the first, and had QuantiFERON reversion after anti-tuberculosis treatment(ATT). To discuss how we manage patient with QuantiFERON reversion.
MethodsCase record of a 25 years old man who had panuveitis in the right eye and QuantiFERON positive. Visual acuity, intraocular pressure, fluorescein angiography, and spectral-domain optical coherence tomography were documented. The management process was also recorded. Papers about QuantiFERON change were reviewed.
ResultsA 25 years old man had panuveitis in the right eye. His blood tests were within normal limits except QuantiFERON positive at another hospital, so he was treated as intraocular tuberculosis. However, after 9-month ATT, his panuveitis in the right eye was not improved and his left eye also developed panuveitis. We re-checked his QuantiFERON at our hospital, and it turned to negative. Under the impression of Bechet’s disease, the rheumatologist started to use golimumab. The patient’s uveitis in eyes became stable.
ConclusionProgressive inflammation following ATT for presumed ocular TB is common. It generally resolves on escalation of steroid therapy. If cases do not respond to increased immunosuppression, it is need to be re-investigated other cause. Interpretation of serial QuantiFERON tests is confounded by immunological and technical variability, and it must be interpreted in conjunction with clinical findings and collaboration with other subspecialties.
Conflict of interestNo
Author 1
Last nameHSIA
Initials of first name(s)NY
DepartmentOphthalmology
CityTaichung
CountryTaiwan
Author 2
Last nameLIN
Initials of first name(s)CJ
DepartmentOphthalmology
CityTaichung
CountryTaiwan
Author 3
Last nameLIN
Initials of first name(s)JM
DepartmentOphthalmology
CityTaichung
CountryTaiwan
Author 4
Last nameCHEN
Initials of first name(s)WL
Departmentophthalmology
CityTaichung
CountryTaiwan
Author 5
Last nameTSAI
Initials of first name(s)YY
DepartmentOphthalmology
CityTaichung
CountryTaiwan