Nl-Fr

View abstract

Presentation preference Poster and Rapid fire
review resultOral
TitlePredictive Factors of Intraocular Pressure Level Evolution Over Time and Glaucoma Severity in Fuchs
Accept poster if oral is not possible ?Yes
PurposeTo investigate the clinical and virological predictive factors of intraocular pressure (IOP)evolution and glaucoma severity in Fuchs Heterochromic Iridocyclitis (FHC)
MethodsConsecutive patients with clinical FHC and intraocular synthesis of rubella(RV)-specific antibodies were included.Specific ocular production of RV antibodies was confirmed using the quotient of serum/aqueous humour ratio of RV IgGs (Crv) and control antiviral IgGs (Cctl). Epidemiological, clinical, biological and virological data at referral were collected and correlated with IOP values over time, occurrence and severity of glaucoma
Results68 eyes of 68 patients were included.Mean age at diagnosis was 40.7±11.1 years.Mean follow-up was 4.3±4.3 years.Mean baseline Crv and Cctl values were 12.34±14.67 and 216.70±98.4.Mean baseline IOP was 17.2±7.2 mmHg [9-40] and 15.6±5.6 [3-30] five years after referral.The predictive factors for pejorative IOP evolution over time and glaucoma severity were male gender (p=0.03) and decreased Crv (p =0.04);and presence of iris nodules (p<0.001) and decreased Cctl (p=0.02) respectively.Diagnostic delay was associated with increased likelihood of undergoing glaucoma surgery (p=0.02)
ConclusionTime to diagnosis,male gender,presence of iris nodules at baseline and decreased Crv and Cctl ratios were associated with increased likelihood of pejorative IOP evolution. Given the aggressiveness of glaucoma in FHC,these results provide interesting insight on what category of patients should need the closest screening
Conflict of interestNo
Author 1
Last nameTOUHAMI
Initials of first name(s)S
CityPARIS
CountryFrance
Author 2
Last nameVANIER
Initials of first name(s)A
CityNANTES
CountryFrance
Author 3
Last nameROSATI
Initials of first name(s)A
CityROME
CountryItaly
Author 4
Last nameBOJANOVA
Initials of first name(s)M
CityPARIS
CountryFrance
Author 5
Last nameBENRHOMDANE
Initials of first name(s)B
CityPARIS
CountryFrance
Author 6
Last nameLEHOANG
Initials of first name(s)P
CityPARIS
CountryFrance
Author 7
Last nameROZENBERG
Initials of first name(s)F
CityPARIS
CountryFrance
Author 8
Last nameBODAGHI
Initials of first name(s)B
CityPARIS
CountryFrance