Efficacy and safety of adalimumab in patients with non-infectious uveitis: a retrospective observational study of 14 patients
Purpose
The study aimed to evaluate the efficacy of adalimumab (ADA) as additional treatment option for the treatment of uveitis.
Methods
Fourteen patients (8 m, 16 eyes and 6 fm, 11 eyes) treated with ADA were enrolled. The mean age was 58.0 years (s.d. 20.6; range, 17-79 years). Demographic, clinical, and therapeutic data such as cases of uveitis, immunosuppressive agents, treatment cessation including its causes and adverse reactions, were retrospectively collected from the medical records and statistically analyzed. The efficacy of ADA was evaluated either for the corticosteroid-sparing effect or for control in ocular inflammation.
Results
Causes of uveitis included Vogt-Koyanagi-Harada disease 57%, Sarcoidosis 14%, uveoscleritis 7%, Behçet's disease 7%, scleroderma 7% and idiopathic uveitis 7%. Eleven patients received ADA for the corticosteroid-sparing effect (n=11), and 8 patients (73%) showed reduction of systemic corticosteroids. These patients were also refractory to the following therapies: methotrexate (n=3), cyclosporine (n=6). All 3 patients for the control in ocular inflammation who received ADA showed discontinuation of ADA as adverse effects such as shingles, non-tuberculous mycobacteriosis, and treatment change for the non-tuberculous mycobacteriosis.
Conclusion
ADA is a significant agent for the treatment of refractory uveitis with steroid dependent. Further investigation of ADA for treatment-resistant uveitis is warranted. The systemic infections need monitoring when ADA is applied in treating non-infectious uveitis.
Conflict of interest
No
Author 1
Last name
YANAI
Initials of first name(s)
R
Department
Ophthalmology
City
Ube
Country
Japan
Author 2
Last name
Uchi
Initials of first name(s)
S-H
Department
Ophthalmology
City
Ube
Country
Japan
Author 3
Last name
Tominaga
Initials of first name(s)
W
Department
Ophthalmology
City
Ube
Country
Japan
Author 4
Last name
Ogata
Initials of first name(s)
T
Department
Ophthalmology
City
Ube
Country
Japan
Author 5
Last name
Kimura
Initials of first name(s)
K
Department
Ophthalmology
City
Ube
Country
Japan
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