Epidemiology of macular edema and epiretinal membrane in patients with uveitis
Purpose
Macular edema (ME) and epiretinal membrane (ERM) in patients with uveitis can cause vision loss. However, ME and ERM have not been studied in a large cohort of uveitis patients. In this study, we examined the prevalence and features of ME and ERM in patients with uveitis.
Methods
1,318 patients (2,017 eyes; 881 eyes in men, 1,136 eyes in women) with mean age of 47.1±19.1 years diagnosed with uveitis diagnosed at Tokyo Medical University Hospital between 2011 and 2016 were analyzed. Retrospective study based on medical chart review. All cases were evaluated at the time of initial visit, and cases in which follow-up was possible for more than 6 months were evaluated. The SS-OCT and/or SD-OCT images of all the subjects were reviewed to assess ME and ERM.
Results
ME and ERM were detected in 7.0% and 6.8%, respectively, of all uveitis patients. At initial visit, high prevalence of ME was found in toxocariasis, Behcet disease and sarcoidosis; while high prevalence of ERM was observed in sarcoidosis, toxocariasis and Behcet disease. The prevalence of ME and ERM in all uveitis cases tended to increase after 6-month follow-up due to new onset cases and cases of stopping follow-up within 6 months.
Conclusion
The Prevalence of ME and ERM differs among diseases of uveitis, suggesting that they may develop via different pathogenic mechanisms. Inflammatory cells and cytokines involving each uveitis may contribute to form ME and ERM.
Conflict of interest
No
Author 1
Last name
YANAGIDA
Initials of first name(s)
C
Department
Tokyo Medical University
City
Tokyo
Country
Japan
Author 2
Last name
Usui
Initials of first name(s)
Y
Department
Tokyo Medical University
City
Tokyo
Country
Japan
Author 3
Last name
Tsubota
Initials of first name(s)
K
Department
Tokyo Medical University
City
Tokyo
Country
Japan
Author 4
Last name
Mitsuhashi
Initials of first name(s)
R
Department
Tokyo Medical University
City
Tokyo
Country
Japan
Author 5
Last name
Nezu
Initials of first name(s)
N
Department
Tokyo Medical University
City
Tokyo
Country
Japan
Author 6
Last name
Kezuka
Initials of first name(s)
T
Department
Tokyo Medical University
City
Tokyo
Country
Japan
Author 7
Last name
Goto
Initials of first name(s)
H
Department
Tokyo Medical University
City
Tokyo
Country
Japan
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