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Presentation preference	Oral presentation
Title	A case of HLA-B27 positive acute anterior uveitis with preceded by severe periodontitis

Purpose	To report a case of HLA-B27 positive acute anterior uveitis (AAU) preceded by severe periodontitis.
Methods	A 26-year-old woman complaining of hyperemia and ocular pain was referred for new-onset uveitis in the right eye. At presentation, slit-lamp examination revealed severe anterior chamber inflammation with hypopyon and synechia. A tentative diagnosis of AAU was made, and treatment was initiated with topical corticosteroids plus subconjunctival injections of betamethasone. At day 5 after the initial visit, there were increased hypopyon and fibrinous material in the anterior chamber. Systemic investigation revealed that the patient had severe periodontitis with an abscessed tooth and HLA-B27 testing came back positive.
Results	For the presumptive diagnosis of HLA-B27 positive AAU, aggressive topical corticosteroids were continued, and gargling with mouthwash was also performed for the periodontitis. The inflammatory reaction in the anterior segment of the right eye subsided markedly by day 13.
Conclusion	Severe oral cavity infection preceded the onset of AAU in our HLA-B27 positive patient, suggesting possible role for antecedent infection triggering intraocular inflammation in genetically predisposed individuals.
Conflict of interest	No

Author 1

Last name	ANDO
Initials of first name(s)	Y
Department	Department of Ophthalmology, Kyorin University School of Medicine
City	Tokyo
Country	Japan

Author 2

Last name	Keino
Initials of first name(s)	H
Department	Department of Ophthalmology, Kyorin University School of Medicine
City	Tokyo
Country	Japan

Author 3

Last name	Nakayama
Initials of first name(s)	M
Department	Department of Ophthalmology, Kyorin University School of Medicine
City	Tokyo
Country	Japan

Author 4

Last name	Watanabe
Initials of first name(s)	T
Department	Department of Ophthalmology, Kyorin University School of Medicine
City	Tokyo
Country	Japan

Author 5

Last name	Hirakata
Initials of first name(s)	A
Department	Department of Ophthalmology, Kyorin University School of Medicine
City	Tokyo
Country	Japan

Author 6

Last name	Okada
Initials of first name(s)	A.A
Department	Department of Ophthalmology, Kyorin University School of Medicine
City	Tokyo
Country	Japan