Killer cell Immunoglobulin-like Receptors and ligands in patients with CMV-Anterior Uveitis
Purpose
Cytomegalovirus Anterior Uveitis（CMV-AU）manifests in immunocompetent individuals of which the mechanisms are unknown. In this study, we have investigated the role of NK cells in CMV-AU. Important determinants that differentiate human NK responses are the Killer Cell Immunoglobulin-like Receptors (KIR) and their ligands, HLA class I subgroups. Combinations of polymorphisms of KIR and HLA are known to be associated with resistance against virus infection and progression.
Methods
KIR ligands in 118 Chinese Singaporean CMV-AU cases were determined using Next Generation Sequencing (NGS). KIR genotypes were determined using a PCR-SSP method. The data was compared against the profiles of the healthy Chinese Singaporean population.
Results
Among HLA-B Bw4 allele groups (80Ile, 80Thr), the frequency of the 80Ile allele group was significantly increased and the frequency of 80Thr allele group was significantly lower in CMV-AU patients compared to those in healthy controls. No difference was observed in the frequencies of ligands for KIR2DL1/2DL3 and the group A haplotype.
Conclusion
Genetic profiles of KIRs and their ligands in CMV-AU contrast to the KIR/HLA associations reported previously for symptomatic systemic primary CMV infection, implying that the immunological mechanisms against CMV are likely distinct.
Conflict of interest
No
Author 1
Last name
YAWATA
Initials of first name(s)
N
City
Fukuoka
Country
Japan
Author 2
Last name
Siak
Initials of first name(s)
J
Department
Singapore Eye Research Institute, Singapore National Eye Centre, National University of Singapore
City
Singapore
Country
Singapore
Author 3
Last name
Chee
Initials of first name(s)
SP
Department
Singapore Eye Research Institute, Singapore National Eye Centre, National University of Singapore
City
Singapore
Country
Singapore
Author 4
Last name
Kawano
Initials of first name(s)
Y
Department
Fukuoka Dental College
City
Fukuoka
Country
Japan
Author 5
Last name
Yawata
Initials of first name(s)
M
Department
National University of Singapore
City
Singapore
Country
Singapore
Author 6
Last name
Sonoda
Initials of first name(s)
KH
Department
Kyushu University
City
Fukuoka
Country
Japan
This website uses cookies to ensure you get the best experience on our website.
Learn more