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TitleLaser flare photometric evaluation of HLA-B27 associated anterior uveitis
Accept poster if oral is not possible ?Yes
PurposeLaser flare photometric (LFP) evaluation of HLA-B27+ anterior uveitis (AU) patients during active inflammation, follow-up and in remission.
MethodsClinical records of 40 patients (40 eyes with AU and 39 quiet eyes) who presented with HLA-B27+ AU and 11 patients (22 eyes) with a history of HLA-B27+ AU in remission for 2 years (control group) were reviewed.
ResultsMean initial flare of the eyes with AU and contralateral eyes were 279,1±247,1 and 7,28±5,9, respectively. The interval between onset of onset of symptoms and initial visit was 5 days [1-30]. There was a significant correlation between time to treatment and initial flare (p = 0.00, rho=0.654). A significant negative correlation between initial flare and initial Snellen visual acuity (p = 0.00, rho=-0.505) was found. A significant correlation was found between initial flare and 1st week and 1st month flare values (p = 0.00, 0.00 / rho=0.887, 0.665, respectively). In 17 patients, flare was 8ph/ms despite absence of anterior chamber (AC) cells at 1st month visit. There was a significant flare difference between the control group (5ph/ms) and 39 contralateral quiet eyes of AU patients (7ph/ms) (p<0.05).
ConclusionHigh flare despite resolution of AC cells indicates ongoing inflammation and the need for prolonged treatment in patients with HLA-B27+ AU.
Conflict of interestYes
Details of conflicting interestsIlknurTugal-Tutkun has received honoraria from AbbVie and lecture fee from Allergan.
Author 1
Last nameORAY
Initials of first name(s)M
DepartmentIstanbul University Istanbul Faculty of Medicine Department of Ophthalmology
CityIstanbul
CountryTurkey
Author 2
Last nameGuner
Initials of first name(s)E
DepartmentIstanbul University Istanbul Faculty of Medicine Department of Ophthalmology
CityIstanbul
CountryTurkey
Author 3
Last nameKabaalioglu Guner
Initials of first name(s)M
DepartmentIstanbul University Istanbul Faculty of Medicine Department of Ophthalmology
CityIstanbul
CountryTurkey
Author 4
Last nameTugal-Tutkun
Initials of first name(s)I
DepartmentIstanbul University Istanbul Faculty of Medicine Department of Ophthalmology
CityIstanbul
CountryTurkey