Non-correspondence of photoreceptor morphology and sensitivity in AZOOR lesions as assessed by AO-OC
Purpose
Evaluation and comparison of retinal morphology (integrity of PR) and function (retinal sensitivity) in eyes with AZOOR.
Methods
In 2 eyes with AZOOR and 1 eye with AZOOR-like retinal lesions images were obtained with a prototype AO-OCT system allowing 3D cellular retinal imaging. MP, SD-OCT and BAF were obtained at center, border of lesions and adjacent areas.
Results
Retinal sensitivity levels in the center of lesions were within normal limits in the AZOOR-like eye and slightly to completely reduced in the 2 AZOOR eyes. Imaging with AO and conventional OCT in corresponding areas revealed a disturbed or complete loss of PR signals at the level of IS/OS and ETPR with hyperautofluorescence on BAF. All border areas showed a weak and disrupted PR signal at the level of IS/OS and ETPR with reduced cone densities at both PR levels.
Conclusion
Our study showed disturbed PR morphology at the level of IS/OS and ETPR in the border and adjacent regions of AZOOR and AZOOR-like lesions despite still preserved retinal function.
Conflict of interest
No
Author 1
Last name
FUNK
Initials of first name(s)
M
Department
Ophthalmology and Optometry, Medical University Vienna
City
Vienna
Country
Austria
Author 2
Last name
Wassermann
Initials of first name(s)
L
Department
Ophthalmology and Optometry, Medical University Vienna
City
Vienna
Country
Austria
Author 3
Last name
Salas
Initials of first name(s)
M
Department
Center for Medical Physics and Biomedical Engineering, Medical University Vienna
City
Vienna
Country
Austria
Author 4
Last name
Deak
Initials of first name(s)
G
Department
Ophthalmology and Optometry, Medical University Vienna
City
Vienna
Country
Austria
Author 5
Last name
Drexler
Initials of first name(s)
W
Department
Center for Medical Physics and Biomedical Engineering, Medical University Vienna
City
Vienna
Country
Austria
Author 6
Last name
Pircher
Initials of first name(s)
M
Department
Center for Medical Physics and Biomedical Engineering, Medical University Vienna
City
Vienna
Country
Austria
Author 7
Last name
Schmidt-Erfurth
Initials of first name(s)
U
Department
Ophthalmology and Optometry, Medical University Vienna
City
Vienna
Country
Austria
Author 8
Last name
Pollreisz
Initials of first name(s)
A
Department
Ophthalmology and Optometry, Medical University Vienna
City
Vienna
Country
Austria
This website uses cookies to ensure you get the best experience on our website.
Learn more