The Efficacy of Systemic Intravenous and Intraarterial Chemotherapy for Advanced Retinoblastoma
Purpose
To determine the efficacy and safety of alternate intravenous chemotherapy (IVC) and intraarterial chemotherapy (IAC) for retinoblastoma patients
Methods
Retrospective, interventional case series of 42 patients with retinoblastoma treated with systemic IVC (carboplatin, vincristine, and etoposide) and IAC (melphalan and/or topotecan).
Results
Forty-two patients were classified by the International Classification of Retinoblastoma as Group D (n=19, 45%) and Group E (n=23, 55%). The mean follow-up duration was 27.3 months. The mean number of IVC was 11 and the mean number of IAC was 4. The overall globe salvage rate was 50.1%. There was no sign of life-threatening complication, metastasis, or death.
Conclusion
IVC-IAC therapy provides globe salvage in 50.1% of retinoblastoma patients (Group D and Group E) with no metastasis.
Conflict of interest
No
Author 1
Last name
LEE
Initials of first name(s)
DH
Department
Department of Ophthalmology, Yonsei University College of Medicine
City
Seoul
Country
Korea, Republic of
Author 2
Last name
HAN
Initials of first name(s)
JW
Department
Department of Pediatric Hematology and Oncology, Yonsei University College of Medicine
City
Seoul
Country
Korea, Republic of
Author 3
Last name
HAHN
Initials of first name(s)
SM
Department
Department of Pediatric Hematology and Oncology, Yonsei University College of Medicine
City
Seoul
Country
Korea, Republic of
Author 4
Last name
KIM
Initials of first name(s)
DJ
Department
Department of Radiology, Yonsei University College of Medicine
City
Seoul
Country
Korea, Republic of
Author 5
Last name
KIM
Initials of first name(s)
BM
Department
Department of Radiology, Yonsei University College of Medicine
City
Seoul
Country
Korea, Republic of
Author 6
Last name
LYU
Initials of first name(s)
CJ
Department
Department of Pediatric Hematology and Oncology, Yonsei University College of Medicine
City
Seoul
Country
Korea, Republic of
Author 7
Last name
LEE
Initials of first name(s)
SC
Department
Department of Ophthalmology, Yonsei University College of Medicine
City
Seoul
Country
Korea, Republic of
Author 8
Last name
LEE
Initials of first name(s)
CS
Department
Department of Ophthalmology, Yonsei University College of Medicine
City
Seoul
Country
Korea, Republic of
This website uses cookies to ensure you get the best experience on our website.
Learn more