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TitleOral Phospholipidic Curcumin in Juvenile Idiopathic Arthritis-Associated Uveitis
Accept poster if oral is not possible ?Yes
PurposeTo evaluate the efficacy and the safety of the adjunctive treatment with curcumin-phosphatidylcholine complex in children affected by Juvenile idiopathic arthritis (JIA) -associated uveitis.
MethodsIn this retrospective, longitudinal study, we treated patients with JIA uveitis and residual low-grade inflammatory activity in the anterior chamber with one tablet of curcumin-phosphatidylcholine complex per day, over a year. Inactivity of uveitis was defined as complete disappearance of flare at the slit-lamp examination and values <10 ph/ms at Laser Flare Meter.
ResultsA total of 22 out of 27 patients (81%) achieved inactivity at the end of the study. Five patients (19%) remained stable throughout the follow-up. Overall, the treatment was safe and well tolerated.
ConclusionAdjunctive therapy with curcumin in patients affected by JIA-associated uveitis improves mild chronic anterior chamber flare and presents a good safety profile. Anterior chamber inflammation should be minimized to avoid sight-threatening complications.
Conflict of interestNo
Author 1
Last nameMISEROCCHI
Initials of first name(s)E
DepartmentDepartment of Ophthalmology, Ospedale San Raffaele Scientific Institute, University Vita-Salute, Mi
CityMilan
CountryItaly
Author 2
Last nameGiuffre
Initials of first name(s)C
DepartmentDepartment of Ophthalmology, Ospedale San Raffaele Scientific Institute, University Vita-Salute, Mi
CityMilan
CountryItaly
Author 3
Last nameCicinelli
Initials of first name(s)MV
DepartmentDepartment of Ophthalmology, Ospedale San Raffaele Scientific Institute, University Vita-Salute, Mi
CityMilan
CountryItaly
Author 4
Last nameMarchese
Initials of first name(s)A
DepartmentDepartment of Ophthalmology, Ospedale San Raffaele Scientific Institute, University Vita-Salute, Mi
CityMilan
CountryItaly
Author 5
Last nameModorati
Initials of first name(s)G
DepartmentDepartment of Ophthalmology, Ospedale San Raffaele Scientific Institute, University Vita-Salute, Mi
CityMilan
CountryItaly
Author 6
Last nameBandello
Initials of first name(s)F
DepartmentDepartment of Ophthalmology, Ospedale San Raffaele Scientific Institute, University Vita-Salute, Mi
CityMilan
CountryItaly