| Presentation preference | Oral presentation |
| Title | The use of Wharton's jelly-derived mesenchymal stem cells (WJSCs) and their conditioned medium (CM) to enhance the corneal nerves regeneration in diabetic rats |
| Purpose | The aim of the study was to investigate the effectiveness of using Wharton's jelly mesenchymal stem cells (WJSCs) and their conditioned medium (CM) to regenerate corneal nerves in rats with diabetic keratopathy. |
| Methods | Male diabetic rats were divided into four groups and received either no treatment, WJSCs, or CM through eye drops. After two weeks of treatment, the researchers examined the rats' corneal sensitivity, epithelial layer integrity, histology, and expression of certain genes and proteins related to nerve growth. |
| Results | The results showed that the WJSC and CM treatments improved corneal nerve regeneration in diabetic rats, as evidenced by increased expression of nerve growth-related genes and proteins and improved corneal thickness. |
| Conclusion | In conclusion, the WJSCs and their CM have a potential role in corneal nerve regeneration. |
| Conflict of interest | No |
Authors 1
| Last name | DEWI |
| Initials of first name(s) | PAS |
| Department | Metropolitan Medical Centre Hospital; Siloam MRCCC Hospital; SILC Lasik Centre |
| City | Jakarta |
| Country | Indonesia |
Authors 2
| Last name | Sitompul |
| Initials of first name(s) | RS |
| Department | Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
| City | Jakarta |
| Country | Indonesia |
Authors 3
| Last name | Pawitan |
| Initials of first name(s) | JA |
| Department | Department of Histology, Faculty of Medicine, Universitas Indonesia |
| City | Jakarta |
| Country | Indonesia |
Authors 4
| Last name | Naroeni |
| Initials of first name(s) | A |
| Department | Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
| City | Jakarta |
| Country | Indonesia |
Authors 5
| Last name | Antarianto |
| Initials of first name(s) | RD |
| Department | Stem Cell Medical Technology Integrated Service Unit, Dr. Cipto Mangunkusumo General Hospital, UI |
| City | Jakarta |
| Country | Indonesia |
