| Presentation preference | Poster presentation |
| Title | Photobiomodulation (PBM) with Near Infrared Light (670 nm) Provides Anti-Inflammatory and Anti-Apoptotic Effects in a Rat Model of Endotoxin-Induced Uveitis (EIU). |
| Purpose | The purpose of this study was to investigate the anti-inflammatory and anti-apoptotic effects of near infrared light (670 nm) in a rat model of endotoxin-induced uveitis (EIU). The study aimed to demonstrate the potential of photobiomodulation (PBM) as a non-invasive and cost-effective therapeutic approach for intraocular inflammatory diseases. |
| Methods | Wistar rats were subjected to EIU induction through intravitreal injection of lipopolysaccharide (LPS). An hour following LPS injection, the rats were exposed to near-infrared light (670 nm) at varying intensities (1500 lux, 3000 lux) for one hour. Retinal function was evaluated using full-field electroretinogram (ffERG), and the rats were sacrificed for further investigation. |
| Results | The results demonstrated a significant improvement in light-adapted response of the ffERG in a dose-dependent manner after PBM. qPCR revealed that near infrared light (670 nm) significantly reduced pro-inflammatory associated mRNA expression, TNF-α, IL-6, nuclear factor kappa B (Nf-κb), IL-4, IL-13, IL-1β, nf-κb, and Gasdermin D (GSDMD). The NLRP3 inflammasome pathway was also inhibited by near infrared light (670 nm). Furthermore, near infrared light exhibited anti-apoptosis effects by downregulating apoptosis-related genes (p53, Bax) and increasing Bcl2 expression. |
| Conclusion | In conclusion, PBM with near infrared light (670 nm) demonstrated anti-inflammatory and anti-apoptotic effects in a rat model of EIU. The results suggest that PBM with near infrared light could potentially serve as a non-invasive and cost-effective therapeutic approach for treating intraocular inflammatory diseases. |
| Conflict of interest | No |
Authors 1
| Last name | LIU |
| Initials of first name(s) | P.K. |
| Department | Department of Ophthalmology, School of Medicine, College of Medicine, Kaohsiung Medical University |
| City | Kaohsiung City |
| Country | Taiwan |
Authors 2
| Last name | Chen |
| Initials of first name(s) | T.W. |
| Department | Institute of Eye Research |
| City | Hualien |
| Country | Taiwan |
Authors 3
| Last name | Wen |
| Initials of first name(s) | Y.T. |
| Department | Institute of Eye Research |
| City | Hualien |
| Country | Taiwan |
Authors 4
| Last name | Tsai |
| Initials of first name(s) | R.K. |
| Department | Institute of Eye Research |
| City | Hualien |
| Country | Taiwan |
