| Presentation preference | Oral presentation |
| Title | MRI white matter abnormalities in children with non-infectious uveitis. |
| Purpose | The aim of this study is to analyse the prevalence of white matter abnormalities (WMA) in children with non-infectious uveitis (NIU). The presence of WMA in these children is important as they are now often treated with anti-TNFα therapy which could worsen pre-existing demyelinating white matter abnormalities. |
| Methods | From the University Medical Center Utrecht, medical records of children, <18 years old, with all types of NIU that underwent a cerebral MRI before starting anti-TNF-α treatment or on medical indication were analysed retrospectively. From the Meyer’s Children’s University Hospital Florence, the medical records of children, <18 years old, that underwent a cerebral MRI as part of their workup were analysed retrospectively. |
| Results | From two tertiary centers, the UMC Utrecht and the Meyer’s Children’s Hospital, a total of 112 children, 35 (31.3%) with anterior uveitis, 30 (26.8%) with intermediate uveitis, one with posterior uveitis (0.89%) and 46 (41.1%) with panuveitis, were included. A total of 29 children (25.9%) showed white matter abnormalities (WMA) on cerebral MRI. In addition, incidental findings included one patient with a glandula pinealis lesion, five patients with cysts, two patients with gliosis, one patient with optic neuritis, one patient with venous angioma, one patient with optic nerve atrophy and one patient with plexus papilloma.
In total, 78.0% of all MRI abnormal findings were seen in non-anterior uveitis patients.
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| Conclusion | In both tertiary centra, white matter abnormalities were frequently found on cerebral MRI, especially in non-anterior uveitis patients. Typically these abnormalities were asymptomatic. |
| Conflict of interest | No |
Authors 1
| Last name | HENDRIKSE |
| first name(s) | J |
| Department | Ophthalmology |
| City | Utrecht |
| Country | Netherlands |
Authors 2
| Last name | Maccora |
| first name(s) | I |
| Department | Rheumatology |
| City | Florence |
| Country | Italy |
Authors 3
| Last name | Koopman-Kalinina Ayuso |
| first name(s) | V |
| Department | Ophthalmology |
| City | Utrecht |
| Country | Netherlands |
Authors 4
| Last name | Brandsma |
| first name(s) | R |
| Department | Pediatric Neurology |
| City | Utrecht |
| Country | Netherlands |
Authors 5
| Last name | Jansen |
| first name(s) | MH |
| Department | Immunology |
| City | Utrecht |
| Country | Netherlands |
Authors 6
| Last name | Nievelstein |
| first name(s) | RAJ |
| Department | Radiology and Nuclear Medicine |
| City | Utrecht |
| Country | Netherlands |
Authors 7
| Last name | Kuiper |
| first name(s) | JJW |
| Department | Translational Immunology |
| City | Utrecht |
| Country | Netherlands |
Authors 8
| Last name | Simonini |
| first name(s) | G |
| Department | Rheumatology |
| City | Florence |
| Country | Italy |
Authors 9
| Last name | de Boer |
| first name(s) | JH |
| Department | Ophthalmology |
| City | Utrecht |
| Country | Netherlands |
