| Presentation preference | Oral presentation |
| Title | SAFETY OF INTRAVENOUS METHYLPREDNISOLONE IN REFRACTORY AND SEVERE PEDIATRIC UVEITIS |
| Purpose | To evaluate the safety of intravenous high-dose pulse methylprednisolone succinate (IVHDM) in the management of severe or refractory non-infectious pediatric uveitis. |
| Methods | We reviewed all uveitis patients who were ≤16 years of age and who received IVHDM with a dose of ≥500 mg per day (1–3 days a month) for at least 3 months during their management at a tertiary care eye hospital. |
| Results | Twenty pediatric patients with severe or refractory uveitis who received IVHDM were identified. Six patients were excluded, the remaining 14 patients received IVHDM for at least 4 months. Age (mean±SD) was 11.9±2.4 years and 50% were female. Duration of treatment was 14.2±7.5 months. Thirteen patients received IVHDM in combination with other immunomodulatory therapy. Except for two outliers, IVHDM was given at a dose of 8–25 mg/kg per infusion. Three major adverse events (AEs) occurred in two patients and the number of AEs (major and minor) strongly correlated with duration of treatment (p=0.004) and moderately correlated with the cumulative dose/weight (p=0.051). |
| Conclusion | IVHDM may be a valid therapeutic option for aggressive/refractory pediatric uveitis. The reported AEs in this series can also be attributed to the concurrent IMT or the underlying disease itself. |
| Conflict of interest | No |
Authors 1
| Last name | SENDINO TENORIO |
| Initials of first name(s) | I |
| Department | Complejo Asistencial Universitario de León |
| City | León |
| Country | Spain |
Authors 2
| Last name | Ghoraba |
| Initials of first name(s) | H |
| Department | pencer Center for Vision Research, Byers Eye Institute, Stanford University |
| City | Palo Alto |
| Country | United States |
Authors 3
| Last name | Matsumiya |
| Initials of first name(s) | W |
| Department | pencer Center for Vision Research, Byers Eye Institute, Stanford University |
| City | Palo Alto |
| Country | United States |
Authors 4
| Last name | Khojasteh |
| Initials of first name(s) | H |
| Department | pencer Center for Vision Research, Byers Eye Institute, Stanford University |
| City | Palo Alto |
| Country | United States |
Authors 5
| Last name | Akhavanrezayat |
| Initials of first name(s) | A |
| Department | pencer Center for Vision Research, Byers Eye Institute, Stanford University |
| City | Palo Alto |
| Country | United States |
Authors 6
| Last name | Karaca |
| Initials of first name(s) | I |
| Department | pencer Center for Vision Research, Byers Eye Institute, Stanford University |
| City | Palo Alto |
| Country | United States |
Authors 7
| Last name | Or |
| Initials of first name(s) | C |
| Department | pencer Center for Vision Research, Byers Eye Institute, Stanford University |
| City | Palo Alto |
| Country | United States |
Authors 8
| Last name | Yavari |
| Initials of first name(s) | N |
| Department | pencer Center for Vision Research, Byers Eye Institute, Stanford University |
| City | Palo Alto |
| Country | United States |
Authors 9
| Last name | Do |
| Initials of first name(s) | D |
| Department | pencer Center for Vision Research, Byers Eye Institute, Stanford University |
| City | Palo Alto |
| Country | United States |
Authors 10
| Last name | Dong Nguyen |
| Initials of first name(s) | Q |
| Department | pencer Center for Vision Research, Byers Eye Institute, Stanford University |
| City | Palo Alto |
| Country | United States |
