Fluocinolone acetonide insert for uveitis: efficacy and experience from a tertiary center
Purpose
Macular oedema (CME) is one of the main causes of visual deterioration in uveitis. Nowadays, good visual acuity (VA) can often be maintained with appropriate treatment as steroid depot systems.
Methods
The aim of our study was to investigate the efficacy of fluocinolone acetonide inserts (FAc, 0.19mg) in the treatment of non-infectious uveitis. A total of 90 injections were followed. Three subgroups were identified. Group A (follow-up of at least 24 months), group B (follow-up of max. 12 months) and group C (intervention, e.g. dexamethasone insert within first 12 months). In our analysis central retinal thickness (CRT), (VA) and intraocular pressure (IOP) were recorded as outcome measures.
Results
The spectrum of uveitis was distributed as: anterior uveitis in group A 5.8%/ group B 9.1%/ group C 16.7%, intermediate uveitis 47%/22.73%/33.3%, posterior uveitis 35.3%/15.9%/22.2%, Panuveitis 5.9%/36.4%/16.7% and other 5.8%/15.91%/11.1%. Distribution of previous dexamethasone inserts: 4.0±4.7/5.3±3.8/9.0±4.7 (M±SD). FAc therapy significantly reduced CRT in all 3 groups (p<0.01) within 1 month of starting therapy. Subsequently, a significant increase in VA after 1 month was observed in groups A and B. However, even after 3 months, there was no significant increase of VA in group C. This trend was confirmed in the long-term follow-up for up to 36 months. An increase in IOP at 6 months was observed in all 3 groups. This increase was reversible in all eyes with glaucoma medication.
Conclusion
Intravitreal administration of the FAc resulted in a reduction of CME with an improvement in VA. We were able to identify a group of non-responders. An initially rising IOP could be treated conservatively and well controlled.
Conflict of interest
No
Authors 1
Last name
PLEYER
Initials of first name(s)
U
Department
Ophthalmology, Charité University Medicine Berlin
City
Berlin
Country
Germany
Authors 2
Last name
Knecht
Initials of first name(s)
V A
Department
Ophthalmology, Charité University Medicine Berlin
City
Berlin
Country
Germany
Authors 3
Last name
Pohlmann
Initials of first name(s)
D
Department
Ophthalmology, Charité University Medicine Berlin
City
Berlin
Country
Germany
Authors 4
Last name
Rübsam
Initials of first name(s)
A
Department
Ophthalmology, Charité University Medicine Berlin
City
Berlin
Country
Germany
Authors 5
Last name
Madrossa
Initials of first name(s)
D
Department
Ophthalmology, Charité University Medicine Berlin
City
Berlin
Country
Germany
Authors 6
Last name
Rau
Initials of first name(s)
S
Department
Ophthalmology, Charité University Medicine Berlin
City
Berlin
Country
Germany
Authors 7
Last name
Lussac
Initials of first name(s)
V
Department
Ophthalmology, Charité University Medicine Berlin
City
Berlin
Country
Germany
This website uses cookies to ensure you get the best experience on our website.
Learn more