| Presentation preference | Poster presentation |
| Title | Long-Term Efficacy and Safety of Topical Ganciclovir Solution in the Treatment of Cytomegalovirus Anterior Uveitis |
| Accept poster if oral is not possible ? | Yes |
| Purpose | To assess the long-term efficacy and safety of 2% topical Ganciclovir solution in treating cytomegalovirus (CMV) anterior uveitis. |
| Methods | This retrospective study involved patients diagnosed with recurrent CMV anterior uveitis via aqueous polymerase chain reaction at NTUH. Excluded were patients under 20 years or with less than 2 years of follow-up. Data collected included age, sex, affected eye, and CMV viral load. Non-treatment duration was defined as the time from the first episode to Ganciclovir initiation. Endothelial cell density (ECD) and retinal nerve fiber layer (RNFL) thickness were measured before and at least 2 years after treatment. Uveitis-related surgeries, including cataract surgery and trabeculectomy, were recorded. Relapse rates, ECD, and RNFL were compared pre- and post-treatment using paired t-tests, and risk factors for surgeries were analyzed via multivariate logistic regression. |
| Results | The study included 32 eyes of 32 patients (mean age: 54.9 ± 12.4 years; 21 men). The average non-treatment duration was 7.0 ± 6.5 years. Pre-treatment and post-treatment relapse rates were 8 ± 7.1 and 1 ± 0.7 episodes/person-year (p < 0.05), with 53.1% of patients having no relapses post-treatment. RNFL thickness significantly decreased (pre-treatment: 73.2 ± 15.2 μm, post-treatment: 70.3 ± 12.9 μm, p = 0.027), while ECD remained stable (pre-treatment: 1540.5 ± 625/mm², post-treatment: 1504.7 ± 801/mm², p = 0.672). Surgical interventions included cataract surgery (50%) and trabeculectomy (34.4%), with no patient characteristics linked to surgical risk. |
| Conclusion | Topical 2% Ganciclovir effectively prevents relapse and maintains ECD in patients with CMV anterior uveitis. |
| Conflict of interest | No |
1
| Last name | YEH |
| Initials of first name(s) | PT |
| Department | Department of Ophthalmology, National Taiwan University Hospital |
| City | Taipei |
| Country | Taiwan |
2
| Last name | Lin |
| Initials of first name(s) | CP |
| Department | Department of Ophthalmology, National Taiwan University Hospital |
| City | Taipei |
| Country | Taiwan |
3
| Last name | Wang |
| Initials of first name(s) | YH |
| Department | Department of Ophthalmology, National Taiwan University Hospital |
| City | Taipei |
| Country | Taiwan |
