| Presentation preference | Poster presentation |
| Title | Acute Retinal Necrosis: A Multicenter Study on Viral Etiology, Characteristics and Risk Factors for Visual Loss and Retinal Detachment |
| Accept poster if oral is not possible ? | Yes |
| Purpose | To investigate the clinical characteristics and factors associated with specific viral pathogens, severe visual impairment (SVI), and retinal detachment (RD) in patients with acute retinal necrosis (ARN) |
| Methods | Retrospective multicenter cohort study. Patients with ARN who underwent aqueous or vitreous polymerase chain reaction (PCR) testing were included. Multivariable mixed-effects Poisson regression identified factors associated with viral pathogens and SVI. A mixed-effects parametric survival-time model assessed RD risk factors. |
| Results | A total of 56 patients (65 eyes) with ARN were included, with a mean age was 39.9 ± 23.2 years. Varicella zoster virus (VZV) was the most common pathogen (30.8%), followed by Herpes simplex virus (HSV) (13.8%), Cytomegalovirus (CMV) (10.8%), Epstein-Barr virus (EBV) (9.2%), and human herpesvirus (HHV) (3.0%). Co-infections were observed in 20% of eyes. CMV-ARN was associated with wedge-shaped retinitis (aPR 4.19) and immunocompromised status (aPR 8.8). Younger age and optic disc edema (aPR 5.41) were correlated with HSV-ARN. SVI was related to zone 1 involvement (aRR 4.2), immunocompromised status (aRR 2.8), and RD (aRR 4.8). RD incidence increased in cases of VZV-ARN, with retinitis affecting 2-3 quadrants and immunocompetent patients. |
| Conclusion | VZV was the predominant viral pathogen. Wedge-shaped retinitis and immunocompromised status were associated with CMV-ARN, which suggests changing antiviral treatment to systemic Ganciclovir.Early and aggressive intervention is essential in VZV cases, particularly when retinitis involves 2-3 quadrants and in immunocompetent individuals, to reduce the risk of RD. |
| Conflict of interest | No |
1
| Last name | SOITONG |
| Initials of first name(s) | P |
| Department | Phramongkhutklao hospital |
| City | Bangkok |
| Country | Thailand |
