| Presentation preference | Oral presentation |
| Title | Multimodal imaging enhanced by indocyanine green angiography in syphilitic uveitis |
| Accept poster if oral is not possible ? | Yes |
| Purpose | To characterize fundus abnormalities associated with syphilitic uveitis (SU) on multimodal imaging (MI) enhanced by indocyanine green angiography (ICGA). |
| Methods | Prospective investigation of patients admitted for treatment of SU at a referral hospital between 2018 and 2019, including 24 patients. Eight patients from a pilot analysis, previously admitted, were also included, comprising 32 patients. MI consisting of ICGA, fluorescein angiography(FA), autofluorescence(FAF), and optical coherence tomography(SD-OCT), upon hospital admission and discharge. Demographic and clinical examination data were analyzed. |
| Results | 62 eyes of 32 patients with sufficiently transparent media were analyzed, with mean age of 43 years, 78% man and 25% with HIV coinfection. VDRL ranged from 1:32-1:4096. MI detected unrecognized posterior segment involvement in 11 eyes, improving the accuracy of uveitis classification by 19% (11/57). ICGA disclosed evidence of choroidal inflammation manifested by geographical hypocyanescence in 27/58 eyes (47%) of 20/32 (63%) patients, dark dots in 33/46 eyes of 22/28 patients (79%) and speckled hipocyanescence in 52/56 eyes (93%) of all 32 patients. On FA, placoid hyperfluorescence was identified in 16/54 eyes (30%) of 13/31 patients (42%). SD-OCT abnormalities were found in 53/59 eyes (89.8%) and ELM disruptions on SD-OCT were associated with of worse BCVA at presentation and upon discharge (P<0.05) |
| Conclusion | MI was superior to clinical ophthalmic examination for detection of inflammation associated with syphilitic uveitis. Choroidal hypocyanescent changes were the most common abnormality revealed by MI. ELM disruption on SD-OCT was predictive of more severe intraocular inflammation before and after therapy |
| Conflict of interest | No |
1
| Last name | CENACHI |
| Initials of first name(s) | S |
| Department | Faculdade de Medicina da Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil |
| City | Belo Horizonte |
| Country | Brazil |
2
| Last name | NETO |
| Initials of first name(s) | V |
| Department | Hospital São Geraldo/HC da Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil |
| City | Belo Horizonte |
| Country | Brazil |
3
| Last name | AZEVEDO |
| Initials of first name(s) | D |
| Department | Hospital São Geraldo/HC da Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil |
| City | Belo Horizonte |
| Country | Brazil |
4
| Last name | CAMPOS |
| Initials of first name(s) | W |
| Department | Faculdade de Medicina da Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil |
| City | Belo Horizonte |
| Country | Brazil |
5
| Last name | Vasconcelos-Santos |
| Initials of first name(s) | DV |
| Department | Faculdade de Medicina da Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil |
| City | Belo Horizonte |
| Country | Brazil |
