| Presentation preference | Poster presentation |
| Title | Long-term outcomes of intravitreal 0.19 mg fluocinolone acetonide implant in uveitic macular edema after prior local corticosteroid treatments |
| Accept poster if oral is not possible ? | Yes |
| Purpose | This study evaluates the long-term efficacy and safety of intravitreal 0.19 mg fluocinolone acetonide implant (FAi) in non-infectious UME, comparing it with prior sub-Tenon's triamcinolone acetonide (STTA) and/or intravitreal dexamethasone implant (DEXAi) |
| Methods | A retrospective review of patients with chronic non-infectious UME who received intravitreal FAi after STTA and/or DEXAi |
| Results | Thirteen eyes from 7 patients (69.2% female) were included, with a mean age of 65±11 years. The median follow-up was 54 months before FAi (IQR: 43–65) and 47 months after FAi(IQR: 23–60). All eyes received at least one STTA, and 11 eyes received at least one DEXAi before FAi. The median number of injections before FAi was 4 (range: 2–8). A significant reduction in recurrences per year was observed after FAi (4.62±1.9 before vs. 0.31±0.5 after, Wilcoxon test, p=0.001). Macular edema relapsed in 4 eyes (30.8%) between months 28 and 36. Central retinal thickness significantly decreased after FAi (474±96 μm before vs. 305±58 μm after, Wilcoxon test, p=0.002). Ten eyes (76.9%) showed BCVA improvement (1–4 lines), and none lost visual acuity. All eyes were pseudophakic prior to FAi. At FAi, four of seven patients were on systemic anti-inflammatory therapy; 3 discontinued it, and none started new treatment after FAi. Five eyes were on topical IOP-lowering medication at the time of FAi; 2 required and increase in treatment, and 2 later underwent trabeculectomy. After FAi, only two eyes started IOP-lowering medication |
| Conclusion | In this case series with long-term follow-up, FAi for UME was effective, safe, and reduced recurrences compared to other local corticosteroids |
| Conflict of interest | No |
1
| Last name | ARAÚJO |
| Initials of first name(s) | J |
| Department | Department of Ophthalmology, Unidade Local de Saúde de São João |
| City | Porto |
| Country | Portugal |
2
| Last name | SILVA |
| Initials of first name(s) | M |
| Department | Department of Ophthalmology, Unidade Local de Saúde de São João |
| City | Porto |
| Country | Portugal |
3
| Last name | TORRES-COSTA |
| Initials of first name(s) | S |
| Department | Department of Ophthalmology, Unidade Local de Saúde de São João |
| City | Porto |
| Country | Portugal |
4
| Last name | OLIVEIRA-FERREIRA |
| Initials of first name(s) | C |
| Department | Department of Ophthalmology, Unidade Local de Saúde de São João |
| City | Porto |
| Country | Portugal |
5
| Last name | PEDROSA |
| Initials of first name(s) | C |
| Department | Department of Ophthalmology, Unidade Local de Saúde de São João |
| City | Porto |
| Country | Portugal |
6
| Last name | FIGUEIRA |
| Initials of first name(s) | L |
| Department | Department of Ophthalmology, Unidade Local de Saúde de São João |
| City | Porto |
| Country | Portugal |
