| Presentation preference | Oral presentation |
| Title | Improved Clinical Outcomes In Patients With Juvenile Idiopathic Arthritis Associated Uveitis |
| Purpose | To analyze the development of ocular complications and visual prognosis in juvenile idiopathic arthritis associate uveitis (JIA-uveitis) compared to the previous decade in the light of new (treatment) guidelines. |
| Methods | Patients were stratified into two cohorts based on the year of diagnosis of uveitis, before 2010 (n=61) and after 2010 (n=82). Development of ocular complications and visual outcomes were analyzed by univariate and multivariate methods. Treatment with systemic corticosteroids and immunomodifying medication (IMT) were documented. |
| Results | In total 109 and 133 affected eyes, respectively for cohort 1 (<2010) and cohort 2 (>2010) were included for analysis. In the multivariate analysis with correction for paired eyes, patients in cohort 1 were significantly more at risk for cataract surgery (P=0.03) and secondary glaucoma (P=0.005). Also, the number of eyes that were legally blind and visually impaired at five years follow-up were significantly higher in cohort 1 (7% vs. 2% and 8% vs. 0%, P=0.01, respectively). In cohort 2 both methotrexate and anti-TNF-α therapy were prescribed earlier in the disease course (1.41 vs 0.05 years, P=8.31 x 10-6 and 6.07 vs 1.84 years, P=5.14 × 10-5, respectively). |
| Conclusion | The visual prognosis of patients with JIA-uveitis diagnosed in the past decennium have improved with less cataract and glaucoma development compared to an earlier cohort. In general these patients are earlier initiated on IMT. |
| Conflict of interest | No |
Authors 1
| Last name | WENNINK |
| Initials of first name(s) | R.W. |
| Department | Ophthalmology |
| City | Utrecht |
| Country | Netherlands |
Authors 2
| Last name | Kalinina Ayuso |
| Initials of first name(s) | V. |
| Department | Ophthalmology |
| City | Utrecht |
| Country | Netherlands |
Authors 3
| Last name | Pameijer |
| Initials of first name(s) | E.M. |
| Department | Ophthalmology |
| City | Utrecht |
| Country | Netherlands |
Authors 4
| Last name | Dekkers |
| Initials of first name(s) | C.C. |
| Department | Ophthalmology |
| City | Utrecht |
| Country | Netherlands |
Authors 5
| Last name | Bozkir |
| Initials of first name(s) | I. |
| Department | Ophthalmology |
| City | Utrecht |
| Country | Netherlands |
Authors 6
| Last name | de Boer |
| Initials of first name(s) | J.H. |
| Department | Ophthalmology |
| City | Utrecht |
| Country | Netherlands |
