This abstract is assigned to sessions
| Presentation preference | Oral presentation |
| Title | Novel Corneal Morphological Alterations in Vogt-Koyanagi-Harada Disease |
| Purpose | To determine whether visual function, especially that dependent on the anterior segment of ocular tissue, was altered during high-dose steroid treatment for Vogt-Koyanagi-Harada disease (VKH). |
| Methods | This case series included 34 eyes of 17 patients with VKH (10 males, 7 females, mean age 48.7 years, range: 22-88 years) who received high-dose steroid therapy as initial treatment. All patients underwent anterior swept-source optical coherent tomography (CASIA-2) examinations during their clinical course to measure the central corneal thickness (CCT), average central corneal power (ACCP), and anterior chamber depth (ACD) at Osaka University Hospital (Osaka, Japan) between January 2018 and May 2020. |
| Results | The duration of treatment was divided into an initial phase (IP; 0-3 months), middle phase (MP; 3-6 months), and late phase (LP; 6-9 months). The alteration rate of the ACCP was significantly reduced in the LP compared to the IP (p<0.05). The CCT decreased significantly after treatment (IP vs. MP, p<0.001; IP vs. LP, p<0.01). The ACCP was correlated with intraocular pressure (IOP) and CCT. The change in CCT was correlated with the visual acuity, IOP, angle depth, and flare at the initial time point. |
| Conclusion | his study was the first to reveal morphological changes in the anterior segment of the eye in VKH using CASIA-2, which may affect visual acuity and the astigmatic axis. It is vital to assess corneal morphology to determine the cause of visual function deterioration in patients with VKH. |
| Conflict of interest | No |
Authors 1
| Last name | MARUYAMA |
| Initials of first name(s) | K |
| Department | Vision Informatics, Osaka University |
| City | Suita |
| Country | Japan |
Authors 2
| Last name | Hamano |
| Initials of first name(s) | Y |
| Department | Ophthalmology, Osaka University |
| City | Suita |
| Country | Japan |
Authors 3
| Last name | Hashida |
| Initials of first name(s) | N |
| Department | Ophthalmology, Osaka University |
| City | Suita |
| Country | Japan |
Authors 4
| Last name | Nishida |
| Initials of first name(s) | K |
| Department | Ophthalmology, Osaka University |
| City | Suita |
| Country | Japan |
