| Presentation preference | Oral presentation |
| Title | Evaluation of serum angiotensin converting enzyme and lymphopenia in presumed sarcoid uveitis |
| Purpose | To evaluate the diagnostic efficacy of elevated serum angiotensin converting enzyme (S ACE) and lymphopenia in presumed sarcoid uveitis. |
| Methods | A retrospective study was conducted on 755 patients with uveitis between January 2019 and June 2020. Demographic, clinical and laboratory data were retrieved. Cases were divided in 2 groups. Group A included presumed sarcoid uveitis and Group B as presumed tubercular uveitis. Measurements of S ACE and lymphocyte count were analysed. |
| Results | The total 755 patients with mean age (41 ± 13 years) were analysed; 440 (58%) males and 315 (42%) females. Presumed sarcoid uveitis (group A) was diagnosed in 50 (6%) patients, tubercular uveitis (group B) in 222 (29%). The mean age in Group A was 42 + 11 years and in Group B was 40 + 12.9 years. Intermediate and posterior uveitis were common anatomical diagnosis in group A (59% and 20%) and in group B (46% and 38%). High S ACE was 76% in group A and 46.4% in group B (p value <0.05). Lymphopenia was in 20.5% in group A and 22.7% in group B (p value >0.05). High S ACE with lymphopenia was noted in 14% of group A versus 8.5% in group B (p value<0.05). Mantoux test was positive in 20% in group A and 70% in group B (p value <0.05). QuantiFERON TB was positive in 20% in group A and 62% in group B (p value <0.05). High resolution computed tomography was positive in 60% in group A and 89% in group B(p value <0.05). |
| Conclusion | A combination of elevated serum ACE and lymphopenia is often associated with sarcoid uveitis rather than used alone. Elevated serum ACE is also seen in tubercular uveitis.
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| Conflict of interest | No |
Authors 1
| Last name | BISWAS |
| Initials of first name(s) | J |
| Department | Uveitis |
| City | Chennai |
| Country | India |
Authors 2
| Last name | Elango |
| Initials of first name(s) | N |
| Department | Uveitis |
| City | Chennai |
| Country | India |
Authors 3
| Last name | Bavaskar |
| Initials of first name(s) | S |
| Department | Uveitis |
| City | Chennai |
| Country | India |
Authors 4
| Last name | Angayarkanni |
| Initials of first name(s) | N |
| Department | Biochemistry |
| City | Chennai |
| Country | India |
