| Presentation preference | Oral presentation |
| Title | Anti-Tubercular Therapy in the Treatment of Tubercular Uveitis |
| Purpose | This updated meta-analysis quantitatively evaluates the efficacy of anti-tubercular therapy (ATT) and corticosteroid or immunosuppressive adjuncts in tubercular uveitis (TBU) patients. |
| Methods | Systematic search of PubMed, EMBASE and Cochrane Library for articles on ATT outcomes in TBU (1 Jan 2000 - 1 Aug 2021). Meta-analysis of proportions to calculate pooled estimates for six treatment outcomes |
| Results | 49 studies reporting data for 4,017 TBU patients were included. In comparative studies, the odds ratio (OR) of inflammatory recurrence was 0.33 (95%CI: 0.19-0.60) for ATT vs no ATT. For ATT, pooled incidence of inflammatory recurrence, inflammatory reduction, complete resolution of inflammation and VA improvement were 13% (95%CI: 9-18), 81% (95%CI: 62-95), 83% (95%CI: 77-89), and 65% (95%CI: 51-78) respectively. Corticosteroids were tapered to <10 mg/day without inflammatory progression in 91% (95%CI: 78-99) of patients, 9% (95%CI: 6-13) were administered concomitant immunosuppressive agents |
| Conclusion | Treatment of TBU with ATT is associated with a high level of control or improvement of inflammation, followed by a two-third improvement in the risk of inflammatory recurrence in TBU patients; only one-seventh of TBU patients have recurrences during follow up. Visual acuity improved in most patients. |
| Conflict of interest | No |
Authors 1
| Last name | AGRAWAL |
| Initials of first name(s) | R |
| Department | National Healthcare Group Eye Institute, Tan Tock Seng Hospital |
| City | Singapore |
| Country | Singapore |
Authors 2
| Last name | BETZLER |
| Initials of first name(s) | BK |
| Department | Yong Loo Lin School of Medicine |
| City | Singapore |
| Country | Singapore |
Authors 3
| Last name | Putera |
| Initials of first name(s) | I |
| Department | University of Indonesia |
| City | Jakarta |
| Country | Indonesia |
Authors 4
| Last name | Testi |
| Initials of first name(s) | I |
| Department | Moorfield Eye Hospital |
| City | London |
| Country | United Kingdom |
Authors 5
| Last name | La Distia Nora |
| Initials of first name(s) | R |
| Department | University of Indonesia |
| City | Jakarta |
| Country | Indonesia |
Authors 6
| Last name | Kempen |
| Initials of first name(s) | J |
| Department | Massachusetts Eye and Ear |
| City | Boston |
| Country | United States |
Authors 7
| Last name | Pavesio |
| Initials of first name(s) | C |
| Department | Moorfields Eye Hospital |
| City | London |
| Country | United Kingdom |
Authors 8
| Last name | Gupta |
| Initials of first name(s) | V |
| Department | Advanced Eye Centre, PGIMER |
| City | Chandigarh |
| Country | India |
