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This abstract is assigned to session Free Paper Session VI: Immunology
Presentation preference Oral presentation
TitleDifferential CXC and CX3C chemokine expression profiles in aqueous humor of patients with specific endogenous uveitic entities
PurposeTo determine the levels of the neutrophil chemoattractants CXCL1, CXCL2, CXCL5, CXCL6 and CXCL8, the T helper 1 (Th1) chemoattractants CXCL9, CXCL10 and CXCL11, the lymphoid chemokines CXCL12 and CXCL13 and the soluble form of the transmembrane chemokines CXCL16 and CX3CL1, in aqueous humor (AH) samples from patients with specific uveitic entities.
MethodsAH samples from patients with active uveitis associated with Behçet’s disease (BD) (n=13), sarcoidosis (n=8), HLA-B27-related inflammation (n=12), Vogt-Koyanagi-Harada (VKH) disease (n=12) and healthy controls (n=9) were assayed with the use of a multiplex assay.
Results: Considering all patients, all chemoattractant levels were significantly higher in patients than in controls. Levels of all neutrophil chemoattractants and CXCL10, CXCL16 and CX3CL1 were significantly higher in nongranulomatous uveitis (BD and HLA-B27-associated uveitis) than in granulomatous uveitis (sarcoidosis and VKH disease), whereas levels of the B cell chemoattractant CXCL13 were significantly higher in granulomatous uveitis than in nongranulomatous uveitis. CXCL13 levels were highest in patients with VKH disease. CXCL9, CXCL11 and CXCL12 levels did not differ significantly.
Conclusion: Inflammation in nongranulomatous uveitis appears to be driven rather by neutrophils and Th1 lymphocytes, whereas B lymphocytes may contribute to the inflammatory process in granulomatous uveitis, particularly in VKH disease.
Conflict of interestNo
Author 1
Initials of first name(s)A.
DepartmentDepartment of Ophthalmology
CountrySaudi Arabia