Nl-Fr

View abstract

This abstract is assigned to session Free Paper Session I: Diagnosis and Monitoring
Presentation preference Oral
review resultOral
TitleA swept-source optical coherence tomography angiography study of choroidal granulomas
Accept poster if oral is not possible ?Yes
PurposeTo compare swept-source optical coherence tomography angiography (SS-OCTA) to gold standard imaging for detection of uveitis choroidal granulomas (CG)
MethodsPatients diagnosed with sarcoid,TB and VKH granulomatous uveitis were scanned using indocyanine green (ICG) angiography, enhanced depth imaging OCT (EDI-OCT), and SS-OCTA with 12×12 mm field centered on the macula and the optic nerve (PLEX Elite 9000®).Two trained and masked readers examined the images and measured the CG using the machines built-in calipers
Results196 CG (97 tubercular,61 sarcoid, 38 VKH related) were visualized by ICGA. EDI-OCT could visualize only 55% of CG detected on ICG. On 12x12 OCTA a total of 183 CG could be visualized in the choroidal slab. Assuming accurate detection of CG by ICGA, we detected true-positive, false-positive, false-negative, and true-negative CG in 183, 1, 0, and 12 eyes by OCTA. The sensitivity and specificity of CG detection was 1.0 and 0.97 for OCTA. Interrater reliability of CGs detection was good for ICGA (k = 0.9) and SS-OCTA (k = 0.8), but moderate for EDI-OCT (k = 0.55). Only CGs with a mean volume over 0.0043 cm3 could be detected by EDI-OCT.
ConclusionSS-OCTA is as sensitive as ICGA, and superior to EDI, in detecting all sizes of CG
Conflict of interestNo
Author 1
Last namePICHI
Initials of first name(s)F
DepartmentEye Institute Cleveland Clinic Abu Dhabi
CityAbu Dhabi
CountryUnited Arab Emirates
Author 2
Last nameNeri
Initials of first name(s)P
DepartmentEye Institute Cleveland Clinic Abu Dhabi
CityAbu Dhabi
CountryUnited Arab Emirates
Author 3
Last nameInvernizzi
Initials of first name(s)A
DepartmentEye Institute Ospedale Luigi Sacco
CityMilan
CountryItaly