A swept-source optical coherence tomography angiography study of choroidal granulomas
Purpose
To compare swept-source optical coherence tomography angiography (SS-OCTA) to gold standard imaging for detection of uveitis choroidal granulomas (CG)
Methods
Patients diagnosed with sarcoid,TB and VKH granulomatous uveitis were scanned using indocyanine green (ICG) angiography, enhanced depth imaging OCT (EDI-OCT), and SS-OCTA with 12×12 mm field centered on the macula and the optic nerve (PLEX Elite 9000®).Two trained and masked readers examined the images and measured the CG using the machines built-in calipers
Results
196 CG (97 tubercular,61 sarcoid, 38 VKH related) were visualized by ICGA. EDI-OCT could visualize only 55% of CG detected on ICG. On 12x12 OCTA a total of 183 CG could be visualized in the choroidal slab. Assuming accurate detection of CG by ICGA, we detected true-positive, false-positive, false-negative, and true-negative CG in 183, 1, 0, and 12 eyes by OCTA. The sensitivity and specificity of CG detection was 1.0 and 0.97 for OCTA. Interrater reliability of CGs detection was good for ICGA (k = 0.9) and SS-OCTA (k = 0.8), but moderate for EDI-OCT (k = 0.55). Only CGs with a mean volume over 0.0043 cm3 could be detected by EDI-OCT.
Conclusion
SS-OCTA is as sensitive as ICGA, and superior to EDI, in detecting all sizes of CG
Conflict of interest
No
Author 1
Last name
PICHI
Initials of first name(s)
F
Department
Eye Institute Cleveland Clinic Abu Dhabi
City
Abu Dhabi
Country
United Arab Emirates
Author 2
Last name
Neri
Initials of first name(s)
P
Department
Eye Institute Cleveland Clinic Abu Dhabi
City
Abu Dhabi
Country
United Arab Emirates
Author 3
Last name
Invernizzi
Initials of first name(s)
A
Department
Eye Institute Ospedale Luigi Sacco
City
Milan
Country
Italy
This website uses cookies to ensure you get the best experience on our website.
Learn more