Diagnostic evaluation of OCT angiography and AF in bilateral diffuse uveal melanocytic proliferation
Purpose
To evaluate the utility of optical coherence tomography angiography (OCTA) and autofluorescence (AF) in visualizing the choroidal vasculature in bilateral diffuse uveal melanocytic proliferation (BDUMP), so as to investigate pathophysiology and also aid in diagnosis.
Methods
We investigated 3 cases of BDUMP. Conventional ophthalmic examinations and swept-source optical coherence tomography (SS-OCT) was performed to evaluate disease progressions. We used AF examination using a scanning laser ophthalmoscope to diagnose and investigated its diagnostic utility over classical fluorescein angiography. We also performed OCTA on two of the cases for the evaluation of choroidal vasculature.
Results
Ophthalmoscopic examinations revealed reddish oval patches within the vascular arcades in each patient. SS-OCT showed thickening and thinning of the RPE, as well as a serous retinal detachment. AF examinations revealed diagnostic giraffe sign, intervening areas of increasing and decreasing AF, indicating BDUMP. OCTA revealed decreased vasculature in the choroidal layer in the two cases. OCTA examinations could also provide a novel way to directly visualize the choroidal vasculature damages, which are the primary site of the BDUMP lesions.
Conclusion
AF accomplished the same diagnostic precision while remaining non-invasive. OCTA findings might be potentially elucidative regarding the pathophysiology at the choroidal layer, where BDUMP lesions primarily exist. Given the limited number of recorded BDUMP cases and relatively unknown pathophysiology, OCTA may prove to be invaluable in visualizing disease progression.
Conflict of interest
No
Author 1
Last name
HASHIDA
Initials of first name(s)
N
Department
Depatment of Ophthalmology, Osaka University Graduate School of Medicine
City
Suita
Country
Japan
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